AIE-active dual-channel fluorescent probe for simultaneous viscosity and HClO detection in ferroptosis, acute liver injury and hepatocellular carcinoma models.

Jiakang Sun, Lidong Cao, Yumeng Liu, Yun Wang, Yong Zhan

Abstract read

In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiakang SunCollege of Life Sciences, China Jiliang University, Hangzhou, 310018, China.

Lidong CaoGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.

Yumeng LiuGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.

Yun WangCollege of Life Sciences, China Jiliang University, Hangzhou, 310018, China.

Yong ZhanCollege of Life Sciences, China Jiliang University, Hangzhou, 310018, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study addresses the technical challenge of simultaneously detecting viscosity and hypochlorous acid (HClO) within the liver disease microenvironment by developing a novel near-infrared (NIR) dual-channel fluorescence probe, BCz-DCN-TPA, based on the aggregation-induced emission (AIE) mechanism. The probe exhibits pronounced fluorescence enhancement at 675 nm (viscosity-responsive) and 465 nm (HClO-responsive), attributed to the restriction of intramolecular motion (RIM) effect and HClO-specific oxidation reactions, respectively. It also possesses high sensitivity, excellent selectivity (toward 15 types of interferents), superior photostability (for more than 300 min), and a low limit of detection (LOD), as low as 0.233 nM, for HClO. Theoretical calculations revealed the ground state and excited state reaction pathways underlying the reaction between HClO and BCz-DCN-TPA.

Indexed as

Aggregation-induced emissionDual-channel responseFluorescent probeNear-infrared imagingPhotoacoustic imagingViscosity and HClO detection

Identifiers

PMID42093674

DOI10.1016/j.jpha.2025.101489

PMCPMC13141041

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.