Evidence map›Paper›PMID 42093312›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2026

The Effects of Radioimmunotherapy and Antibiotics on Biofilm-Associated Implant Infections in a Preclinical Rat Model.

F Ruben H A Nurmohamed, Kevin J H Allen, Mackenzie E Malo, Connor Frank, Colleen Nesbitt, J Fred F Hooning van Duyvenbode, Michelle Buijs, Berend van der Wildt, Alex J Poot, Marnix G E H Lam and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Effects of Radioimmunotherapy and Antibiotics on Biofilm-Associated Implant Infections in a Preclinical Rat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

F Ruben H A NurmohamedCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
Kevin J H AllenCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
Mackenzie E MaloCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
Connor FrankCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
Colleen NesbittDepartment of Orthopedics, University of Saskatchewan, Saskatoon, Canada.
J Fred F Hooning van DuyvenbodeDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Michelle BuijsDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Berend van der WildtDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Alex J PootDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Marnix G E H LamDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Jos A G van StrijpDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-6253-0830
Johannes M van der MerweDepartment of Orthopedics, University of Saskatchewan, Saskatoon, Canada.
H Charles VogelyDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Harrie WeinansDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Bart C H van der WalDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Ekaterina DadachovaCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indwelling medical implants are susceptible to developing biofilm-associated infections that are notoriously difficult to eradicate. These persistent infections often cannot be resolved with antibiotics alone and typically require surgical intervention for effective management. An alternative approach is radioimmunotherapy (RIT) which uses specific antibodies linked to radioisotopes to selectively destroy bacteria. This antimicrobial approach bypasses traditional antibiotic mechanisms, and RIT is hypothesized to enhance outcomes beyond antibiotic therapy alone. RIT bactericidal effects were studied in Wistar Han rats fitted with femoral rod implants covered by matured 3-day biofilms. The rats (six per group) were treated with either: RIT with

Indexed as

Anti-Bacterial AgentsBiofilmsProsthesis-Related InfectionsRadioimmunotherapyStaphylococcal InfectionsVancomycinAnimalsDisease Models, AnimalMaleRadioisotopesRatsRats, WistarStaphylococcus aureusAnti-Bacterial AgentsRadioisotopesVancomycin177Lutetiumprosthetic joint infectionsradioimmunotherapyrat pre‐clinical modelS. aureusvancomycin

Identifiers

PMID42093312
PMCPMC13150401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.