Evidence map›Paper›PMID 42093157›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

An RYR2-interacting fragment of MYBPC3 mitigates arrhythmia in human iPSC-CM and mouse models of CPVT.

Fujian Lu, Zexuan Wu, Shaopeng Chi, Jiajin Li, Anna Ponek, Carter Liou, Qing Ma, Durgesh Bonde, Nikoleta Pavlaki, Mason E Sweat and 5 more

Abstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fujian LuDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: fujianlu@fudan.edu.cn.
Zexuan WuDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Shaopeng ChiDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Jiajin LiDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Anna PonekDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Carter LiouDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Qing MaDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Durgesh BondeDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Nikoleta PavlakiDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Mason E SweatDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Sanam ShafaattalabDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Yashasvi TharaniDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Maksymilian ProndzynskiDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
Vassilios J BezzeridesDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: vassilios.bezzerides@cardio.chboston.org.
William T PuDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: william.pu@cardio.chboston.org.

Funding

CMYA5 regulation of cardiac dyad structure and functionR01HL163937 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI William Tswenching Pu · 2023 to 2026
$2.4M
NHLBI NIH HHS R01 HL163937
6 · The paper itself

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia caused by pathogenic variants in RYR2 that increase its diastolic Ca

Indexed as

Arrhythmias, CardiacCarrier ProteinsInduced Pluripotent Stem CellsMyocytes, CardiacRyanodine Receptor Calcium Release ChannelTachycardia, VentricularAnimalsDependovirusDisease Models, AnimalGenetic VectorsHumansMiceMyosin Binding Protein CPolymorphic Catecholaminergic Ventricular TachycardiaCarrier ProteinsMyosin Binding Protein CRyanodine Receptor Calcium Release ChannelarrhythmiaCPVTgene therapyMYBPC3RYR2

Identifiers

PMID42093157
PMCPMC13316790

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.