Evidence map›Paper›PMID 42093110›Full record

ReviewImmunity, inflammation and disease2026

Trends and Research Hotspots in Biomarkers of Sjögren's Syndrome Over the Past Two Decades: A Data-Driven Atlas Analysis.

Xinyan Zhang, Huan Li, Xueqing Zhou, Shangwen Qi, Songwei Li

Abstract readReview
In one paragraph

Review in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyan ZhangThe First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China.ORCID https://orcid.org/0009-0007-6043-3114
Huan LiThe First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Xueqing ZhouThe First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Shangwen QiThe First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Songwei LiDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.ORCID https://orcid.org/0009-0001-5213-9042

Funding

Henan Province Chinese Medicine Scientific Research Special Project 2023ZY1010Henan Provincial Science and Technology Research Project 252102311247National Natural Science Foundation of China 81874465Traditional Chinese Medicine Special Research Project of National Administration of Traditional Chinese Medicine GZY-KJS-2025-080
6 · The paper itself

Abstract

backgroundSjögren's syndrome (SS) is a chronic, systemic inflammatory disorder primarily characterized by dry eyes and dry mouth, often involving multiple organ systems. The disease's heterogeneous clinical presentation and the absence of non-invasive, specific biomarkers complicate its diagnosis and prognostic assessment.

methodsLiterature was sourced from the Web of Science Core Collection, and a bibliometric network was constructed using VOSviewer, CiteSpace, and Bibliometrix. This analysis covered countries/regions, institutions, journals, authors, citations, and keywords, offering an overview of SS biomarker research and identifying future directions.

resultsA total of 1118 articles on SS biomarkers were analyzed. Publication trends fluctuated over the years, with China and the United States leading in volume and citation frequency. The Assistance Publique-Hôpitaux de Paris was the most prolific institution. Among researchers, Xavier Mariette dominated the field, with leading positions in volume of publications, h-index, and total citations. Annals of the Rheumatic Diseases emerged as the most influential journal. Over the past two decades, research has expanded significantly, with emerging themes including "DNA methylation," "genes," "interstitial lung disease," and "data-driven," indicating future focus areas such as epigenetics, severe complication biomarkers, and multi-omics studies.

conclusionThis bibliometric analysis provides a comprehensive view of SS biomarker research, highlighting recent trends and future research directions, offering valuable insights for ongoing studies.

Indexed as

BiomarkersBiomedical ResearchSjogren's SyndromeBibliometricsHumansBiomarkersbibliometricsbiomarkershotspot analysisSjögren's syndrome

Identifiers

PMID42093110
PMCPMC13149753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.