Evidence map›Paper›PMID 42093079›Full record

ArticlePest management science2026

Structural evolution of quinine derivatives for enhanced antifungal potency: key modifications and quantitative structure-activity relationship (QSAR) analysis.

Lihong Fan, Ye Wu, Yining Lei, Yizhou Liu, Mingxuan Li, Chunxia Chen, Hanbao Zhang, Lianxu Shi, Jinsong Peng

Abstract read
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Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lihong Fan *College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.ORCID https://orcid.org/0009-0005-0237-0720
Ye Wu *College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Yining LeiCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Yizhou LiuCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Mingxuan LiCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Chunxia ChenCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Hanbao ZhangCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.ORCID https://orcid.org/0009-0005-5671-1981
Lianxu ShiCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Jinsong PengCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.

Funding

Fundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of ChinaNatural Science Foundation of Heilongjiang Province
6 · The paper itself

Abstract

backgroundThe escalating resistance of phytopathogenic fungi to conventional fungicides, combined with increasing environmental concerns, necessitates the development of novel bioactive agents.

resultsIn this study, utilizing the natural product quinine as a lead scaffold, a series of novel 2-aminoquinine derivatives were designed and synthesized via PyBroP-mediated amination. The antifungal activities of these compounds against seven plant pathogens, including Rhizoctonia solani (R. solani), Cytospora chrysosperma (C. chrysosperma), Fusarium oxysporum (F. oxysporum), Magnaporthe oryzae (M. oryzae), Fusarium graminearum (F. graminearum), Sphaeropsis sapinea (S. sapinea), and Botrytis cinerea (B. cinerea), were evaluated using the mycelial growth rate method. Among the synthesized derivatives, compound Qed-3 exhibited broad-spectrum efficacy, particularly against S. sapinea with a half-maximal effective concentration (EC

conclusionsMolecular docking and quantitative structure-activity relationship (QSAR) analyses provided insights into the binding modes and structural determinants essential for antifungal potency. These findings highlight the potential of 2-arylaminoquinine as a promising and eco-friendly candidate for novel fungicide development. © 2026 Society of Chemical Industry.

Indexed as

Antifungal AgentsBotrytisFusariumQuantitative Structure-Activity RelationshipQuinineFungicides, IndustrialMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionMolecular Docking SimulationPlant DiseasesReactive Oxygen SpeciesRhizoctoniaAntifungal AgentsFungicides, IndustrialQuinineReactive Oxygen Speciesfungicidemolecular dockingQSARquinine derivativessynthesis

Identifiers

PMID42093079
PMCPMC13352248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.