Evidence map›Paper›PMID 42093077›Full record

ArticleThe Laryngoscope2026

Finite Element Analysis of Upper Airway in Ansa Cervicalis Stimulation for Obstructive Sleep Apnea.

Mukund Gupta, Songrui Li, Haoxiang Luo, David T Kent, Yike Li

Abstract read
In one paragraph

Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mukund GuptaDepartment of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0009-0003-4081-7920
Songrui LiDepartment of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Haoxiang LuoDepartment of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-1984-1040
David T KentDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-8183-5269
Yike LiDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-8465-130X

Funding

The Effect of Ansa Cervicalis Neurostimulation on Airway Patency in Obstructive Sleep ApneaR01HL161635 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David T. Kent · 2022 to 2026
$3.9M
NHLBI NIH HHS R01 HL161635NIH HHS R01HL161635
6 · The paper itself

Abstract

objectiveTo develop a subject-specific, three-dimensional finite element (FE) model of the human upper airway and evaluate how ansa cervicalis stimulation (ACS), a novel neurostimulation for obstructive sleep apnea (OSA), alters upper airway anatomy under physiologic loading.

methodsUpper airway anatomy was reconstructed from a head-and-neck CT of an adult female using a semi-automated pipeline, including segmentation, smoothing, tetrahedral meshing, and registration. Linear elastic material properties were assigned from the literature. ACS was simulated as a caudal load on the anterior thyroid cartilage, and inspiratory collapse tendency was mimicked with a -70 Pa luminal negative pressure. Structural displacement and cross-sectional area (CSA) changes were quantified at the soft palate, lateral pharyngeal wall, tongue base, and epiglottis.

resultsACS produced caudal displacement of the thyroid cartilage by approximately 10 mm with coordinated motion of the hyolaryngeal complex and longitudinal pharyngeal wall strain. It also tilted the epiglottis antero-inferiorly and increased its curvature, reducing posterior-inferior motion under negative pressure by more than 50% (5.0 to 2.2 mm). Retro-epiglottic CSA increased by 68.8% without negative pressure (42.43 to 71.63 mm

conclusionThis proof-of-concept, subject-specific FE model shows that ACS imparts caudal traction through the hyolaryngeal complex, producing multilevel anatomic stabilization under physiologic loading. The findings establish a quantitative, hypothesis-generating framework for interrogating ACS-mediated airway stabilization mechanisms and support further investigation across broader OSA populations and collapse phenotypes. LEVEL OF EVIDENCE: N/A.

Indexed as

Electric Stimulation TherapyFinite Element AnalysisSleep Apnea, ObstructiveAdultEpiglottisFemaleHumansImaging, Three-DimensionalPalate, SoftPharynxThyroid CartilageTomography, X-Ray Computedansa cervicalis stimulationcaudal tractionfinite element modelingobstructive sleep apneaupper airway biomechanics

Identifiers

PMID42093077
PMCPMC13569699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.