ArticleCell & bioscience2026
Targeting the 5-HT
Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
Abstract
Hypertension, a chronic condition, has affected > 1 billion people worldwide and is linked to a heightened risk of anxiety disorders. Despite this association, the exact mechanisms underlying the connections between hypertension and anxiety disorders remain largely elusive. In this research, we observed that systolic blood pressure (SBP) increased in mice subcutaneously administered with angiotensin II (Ang II) alongside signs of heightened anxiety. Furthermore, immunofluorescence and electrophysiological analyses revealed that Ang II enhanced neuronal activity and altered the synaptic activities of ventral CA1 (vCA1) neurons. Meanwhile, in vivo recordings showed that these neurons in Ang II-treated mice were significantly more responsive to anxiety-inducing stimuli. Additionally, chemogenetic inhibition of neural activity in vCA1 effectively alleviated anxiety-like behavior in the treated animal. Moreover, the expression of the serotonin receptor 5-HT
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