Evidence map›Paper›PMID 42092862›Full record

ArticleBMC nephrology2026

Pediatric to adult transition in chronic kidney disease: a scoping review.

Zachariah Alkhayri, Rama Safadi, Andrea Varghese, Mustafa Husein, Shay Tanna, Sahithi R Mallyala, Nikhil Rayarakula, Carol L Vincent, Rupesh Raina

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zachariah AlkhayriCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.
Rama SafadiCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.
Andrea VargheseCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.
Mustafa HuseinCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.
Shay TannaDepartment of Nephrology, Akron Nephrology Associates, Cleveland Clinic Akron General Medical Center, Akron, OH, USA.
Sahithi R MallyalaDepartment of Nephrology, Akron Nephrology Associates, Cleveland Clinic Akron General Medical Center, Akron, OH, USA.
Nikhil RayarakulaDepartment of Nephrology, Akron Nephrology Associates, Cleveland Clinic Akron General Medical Center, Akron, OH, USA.
Carol L VincentSection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Rupesh RainaDepartment of Nephrology, Akron Nephrology Associates, Cleveland Clinic Akron General Medical Center, Akron, OH, USA. rraina@akronchildrens.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic kidney disease (CKD) presents unique medical and psychosocial challenges in children and adolescents that differ from adult patients with CKD. Transitioning from pediatric to adult care is a critical period. Insufficient planning and inadequate preparation increase the risk of medication nonadherence, loss to follow-up, graft failure in transplant patients, and increased morbidity. Transition models address barriers to successful transition, yet vary in their approach.

methodsWe conducted a scoping review of the transition of care in pediatric CKD in accordance with PRISMA-ScR guidelines. We included PubMed/MEDLINE full-text articles, KDIGO guidelines, and grey literature on transition models between 1st January 2000 and 31st August 2025. Eligible studies included original research articles in English, human clinical trials, and guidelines specifically addressing pediatric-to-adult CKD transition of care.

resultsWe identified barriers to effective transition at the patient, provider, and system levels. Patients often lacked health literacy, emotional readiness, or independence. Providers faced challenges with communication across pediatric and adult care teams. System-level obstacles included gaps in insurance coverage and limited resources. To assess readiness, models such as ON TRAC, TRAQ, RTQ, and the UNC TRxANSITION offer valuable questionnaires. Early preparation between the ages of 11-14, a gradual increase in patient autonomy, multidisciplinary teams' involvement, and structured transfer clinics are recommended for proper CKD transition. DISCUSSION: An effective transition is vital for improving both pediatric and adult health outcomes. Future research should focus on standardized protocols such as the Six Core Elements of Health Care Transition and the integration of technology-based tools to better engage adolescent patients. Structured and evidence-based transition models supported by healthcare systems can improve transition.

Indexed as

Renal Insufficiency, ChronicTransition to Adult CareAdolescentAdultChildHumansAdolescent health servicesAdolescentsChronic kidney diseasePatient compliancePediatricsTransitional care modelsTransition of careTransition to adult care

Identifiers

PMID42092862
PMCPMC13317158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.