ArticleBMC cancer2026
Evaluation of the abscopal-like effect of radioimmunotherapy on sentinel lymph nodes in H22 hepatocellular carcinoma via dynamic lymphography.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe synergistic suppressive effects of the radioimmunotherapy-induced abscopal effect on distant non-irradiated tumors have recently emerged as a research hotspot. However, studies on its specific regulatory role in adjacent sentinel lymph nodes (SLNs) remain limited. The deep location and small size of SLNs hinder the monitoring of treatment-related changes, underscoring the need for lymphography-based approaches. In this study, we aimed to evaluate the abscopal-like effect of radioimmunotherapy on SLNs in an H22 hepatocellular carcinoma mouse model via dynamic lymphography.
methodsH22 murine hepatocarcinoma cells were transplanted into the right hind foot sole of C57BL/6 mice. Fourteen days post-inoculation, mice with SLNs were selected and divided into six groups: control, isotype control Ig, anti-PD-1 alone, irradiation (IR) alone, irradiation + isotype control Ig, and IR + anti-PD-1. The volume and weights of tumors and non-irradiated SLNs were measured. The SLNs were imaged with ¹⁸F-fluorodeoxyglucose (
resultsIn this mouse model, the IR + anti-PD-1 combination treatment exerted a marked suppressive effect on the growth of both irradiated tumors and non-irradiated SLNs, demonstrating a robust enhancement of the abscopal-like effect compared with the monotherapy groups. Mechanistic investigations demonstrated elevated CD8⁺ T cell infiltration in non-irradiated SLNs, suggesting that enhanced systemic anti-tumor immunity mediated the effect. Dynamic ¹⁸F-FDG PET lymphography enabled clear visualization of SLNs as early as 30 s post-injection, with sustained imaging clarity for over 30 min. This method also demonstrated decreased radioactive accumulation in irradiated tumors and non-irradiated SLNs, confirming an enhanced abscopal-like effect with the IR and anti-PD-1 combination approach.
conclusionsOur data demonstrate that the regression of SLNs adjacent to the irradiation field, mediated by the abscopal-like effect of radioimmunotherapy, can be sensitively and effectively tracked via dynamic
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.