Evidence map›Paper›PMID 42092683›Full record

ArticleAnaerobe2026

A diabetic mouse model of early stages of Clostridium perfringens -gas gangrene.

Francisco A Uzal, Jihong Li, Juliann Beingesser, Jessica Banuelos, Mauricio A Navarro, Bruce A McClane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anaerobe, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francisco A UzalCalifornia Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California-Davis, San Bernardino, CA, USA. Electronic address: fauzal@ucdavis.edu.
Jihong LiDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Juliann BeingesserCalifornia Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California-Davis, San Bernardino, CA, USA.
Jessica BanuelosCalifornia Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California-Davis, San Bernardino, CA, USA.
Mauricio A NavarroCalifornia Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California-Davis, Turlock, CA, USA.
Bruce A McClaneDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

Evaluating the role of branched chain amino acid transporters in Clostridium perfringens-induced gas gangrene in diabetic and normal mouse modelsR21AI178207 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, JIHONG, MC CLANE, BRUCE A · 2023 to 2024
$427k
NIAID NIH HHS R21 AI178207
6 · The paper itself

Abstract

introductionSince Clostridium perfringens gas gangrene is strongly associated with human diabetes, this study compared gas gangrene severity in db/db (a model for type 2 diabetes) vs wild-type (WT) mice after a 4 h C. perfringens challenge. MATERIAL AND

methodsBefore C. perfringens challenge, glucose and branched chain amino acids (BCAA) concentrations were significantly higher in db/db vs. WT mice. All mice were then inoculated intramuscularly in, i) the left thigh with DPBS containing 10

resultsGross and microscopic lesions in the left thigh were influenced by bacterial dose. With 10 DISCUSSION: This study supports the usefulness of db/db mice to study C. perfringens gas gangrene pathogenesis in diabetics. It also suggests that higher BCAA and glucose levels and/or stronger upregulation of toxin production in db/db mice may be factors that help cause the development of more severe lesions during the early stages of gas gangrene in the db/db mice.

Indexed as

Clostridium perfringensDiabetes Mellitus, Type 2Gas GangreneAnimalsDisease Models, AnimalHumansMaleMice

Identifiers

PMID42092683
PMCPMC13309878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.