Evidence map›Paper›PMID 42092392›Full record

ArticleDevelopmental cognitive neuroscience2026

Surface expansion regionalization of the hippocampus in early brain development.

Ya Wang, Liangjun Chen, Zhengwang Wu, Sheng-Che Hung, J Keith Smith, Li Wang, Tengfei Li, Weili Lin, Gang Li

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In one paragraph

Article in Developmental cognitive neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ya WangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
Liangjun ChenDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
Zhengwang WuDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
Sheng-Che HungDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
J Keith SmithDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
Li WangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
Tengfei LiDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
Weili LinDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA.
Gang LiDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA. Electronic address: gang_li@med.unc.edu.

Funding

Mapping the Causal Genetic-Imaging-Clinical Pathway for Alzheimer's DiseaseRF1AG082938 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bingxin Zhao, Hongtu Zhu · 2023 to 2026
$3.6M
SCH: Using Data-Driven Computational Biomechanics to Disentangle Brain Structural Commonality, Variability, and Abnormality in ASDR01NS135574 · NINDS · UNIVERSITY OF GEORGIA · PI Xianqiao Wang · 2023 to 2026
$1.1M
NIA NIH HHS RF1 AG082938NINDS NIH HHS R01 NS135574
6 · The paper itself

Abstract

The hippocampus is implicated in a myriad of crucial functions, particularly centered around memory and emotion, with distinct or multiple subdivisions fulfilling specific roles. However, its heterogeneity is multidimensional, given that the functional connectivity and gene expression-based parcellation along its long axis differs from histology-based parcellation along medial-lateral axis. The rapid nonuniform surface expansion of the hippocampus during early development reflects underlying changes of microstructure and functional establishment, providing important clues. Furthermore, the thin and convoluted properties bring out hippocampal maturity largely in the form of expanding surface area. We thus unprecedentedly explore the development-based surface area regionalization and patterns of the hippocampus by leveraging 513 high-quality longitudinal MRI scans during the first two postnatal years. Our findings imply two discrete hippocampal developmental patterns, featuring one pattern of subdivisions along anterior-posterior axis (head, regions 1 and 5; body, regions 2, 4, 6, and 7; tail, region 3) and the other one along medial-lateral axis (subiculum, regions 4, 5, and 6; CA fields, regions 1, 2, and 7). The resulting 7 subdivisions exhibit region-specific and nonlinear spatiotemporal surface area expansion patterns. These results provide important references for exploring fine-grained organization and development of the hippocampus and its intricate cognitions.

Indexed as

HippocampusChild, PreschoolFemaleHumansInfantLongitudinal StudiesMagnetic Resonance ImagingMaleNeurodevelopmentDevelopmental trajectoryInfant hippocampusMRISurface area

Identifiers

PMID42092392
PMCPMC13157169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.