ArticleCell reports methods2026
Human cerebral organoids with microglia and vasculature model glioma stem cell interactions and radiotherapy response.
Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Modeling pediatric brain tumors with human stem cells.Frontiers in cellular neuroscience · 2026Review
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Authors and funding
10 authors.
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Abstract
Most human brain organoid models derived from induced pluripotent stem cells (iPSCs) lack vascular and/or immune components, despite their critical roles in maintaining brain homeostasis and contributing to pathophysiological processes. We established a method for generating vascularized complex cerebral organoids (CCOs) containing microglial cells (brain-resident macrophages) by incorporating bipotent hematopoietic/endothelial progenitors derived from the same iPSC lines. This approach led to the formation of extensive vascular-like structures with blood-brain barrier characteristics, which were perfused upon transplantation into immunodeficient mice. Additionally, microglial cells exhibiting typical phenotypes also developed within the CCOs. By co-culturing CCOs with glioma stem cells, we demonstrated that this model recapitulates the tumor niche of glioblastoma, showing vascular co-option, reprogramming of microglia into tumor-associated macrophages, and recurrence after radiotherapy. In conclusion, our vascularized, immunocompetent CCO model provides a platform to study brain development, glioma pathogenesis, and therapies.
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