Evidence map›Paper›PMID 42092345›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Abi3

Claire A Butler, Min Sung Gee, Katie O'Gara, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Yueh-Hao Lu, Nellie Kwang, Kate I Tsourmas, Christiana Prekopa and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Aberrant phase separation from a rare ABI3 mutation drives microglial dysfunction and Alzheimer's risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Claire A ButlerDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Min Sung GeeDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Katie O'GaraDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Giedre MilinkeviciuteInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Celia Da CunhaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Shimako KawauchiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Yueh-Hao LuInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Nellie KwangDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Kate I TsourmasDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Christiana PrekopaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Zechuan ShiDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Heidi Yahan LiangDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Sherilyn D CollinsTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Zachary A PashkutzInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Jenna A SanchezInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Kai-Xuan ShiTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Amber D WalkerInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Shuling WangTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Maigan L A WongInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Karina GenaroInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Jonathan NeumannTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Angela Gomez-ArboledasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Duc M DuongARCProteomics, Atlanta, Georgia, USA.
Nicholas T SeyfriedGoizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Andrea J TennerDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Frank M LaFerlaDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Ali MortazaviDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Vivek SwarupDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Grant R MacGregorInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Kim N GreenDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, FRANK M LAFERLA · 2017 to 2026
$71.9M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Origins, properties, and therapeutic potential of cells that repopulate the microglia-depleted adult brainR01NS083801 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2014 to 2026
$5.6M
Role of Disease-Associated Microglia in Alzheimer's diseaseR01AG081599 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2024 to 2026
$2.3M
Chao Family Comprehensive Cancer Center P30CA62203NCI NIH HHS P30 CA062203NIA NIH HHS R01 AG081599NIA NIH HHS U54 AG054349NINDS NIH HHS R01 NS083801
6 · The paper itself

Abstract

backgroundGenetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD-associated ABI3

methodsAn Abi3

resultsAbi3 DISCUSSION: Abi3

Indexed as

Adaptor Proteins, Signal TransducingAlzheimer DiseaseCytoskeletal ProteinsMicrogliaPlaque, AmyloidAmyloid beta-PeptidesAnimalsDisease Models, AnimalHumansMiceMice, TransgenicAdaptor Proteins, Signal TransducingAmyloid beta-PeptidesCytoskeletal ProteinsABI3Alzheimer's diseaseAβcell deathmicroglia

Identifiers

PMID42092345
PMCPMC13149227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.