ArticleNature2026
Non-invasive profiling of the tumour microenvironment with spatial ecotypes.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Opinion and perspectives on artificial intelligence biology.Quantitative biology (Beijing, China) · 2026Article
- Review
- Spatial multi-omics uncovers an invasive-desmoplastic cellular community with prognostic and therapeutic implications in pancreatic ductal adenocarcinoma.Advanced biotechnology · 2026Article
- Review
- The RNA cargo of plasma-derived extracellular vesicles in mCRPC patients captures cancer cells and tumor microenvironment signals.bioRxiv : the preprint server for biology · 2026Article
- A Dual-Mode In Situ EV-miRNA Profiling Platform for Machine-Learning-Assisted Gastric Cancer Liquid Biopsy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microenvironment-aware transcriptome reconstruction in spatial transcriptomics.Nature communications · 2026Article
- Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies.Molecular cancer · 2026Review
- Landscape of Cell States and Multicellular Ecotypes in Non-Small Cell Lung Cancer.International journal of molecular sciences · 2026Article
- FlowSpot Enables Decentralized Phenotypic and Functional Cellular Immune Profiling from Dried Blood Spots.bioRxiv : the preprint server for biology · 2026Article
- Metabolism and Immunity-Adapted Radiotherapy (M.I.A.R): A Conceptual Framework for Overcoming the Therapeutic Plateau in Clinical Radiotherapy.Current oncology (Toronto, Ont.) · 2026Review
- Spatially resolved T cell receptor tracking reveals γδT cell localization to tumor-rich regions in high-risk neuroblastoma: A Report from the Children's Oncology Group.medRxiv : the preprint server for health sciences · 2026Article
- Spatial organization of intratumoral microbiome and regional tumor immunity.Frontiers in immunology · 2026Review
- Deciphering immunosuppressive niches by spatial single-cell proteomics: spatial interaction networks and translational opportunities.Frontiers in immunology · 2026Review
- Article
- BAG3Frontiers in immunology · 2026Article
- Resistance mechanisms and reversal strategies of PD-1/PD-L1 inhibitors in melanoma.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Wubing Zhang *Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Erin L Brown *Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0004-3487
Abul Usmani *Division of Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5485-7323
Noah EarlandDivision of Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Minji KangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0009-4249
Chibuzor OleleweDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Anushka ViswanathanDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0009-0004-8140-8936
Pradeep S ChauhanDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Chloé B SteenDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
Hyun Soo JeonDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8388-2480
Susanna AvagyanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Irfan AlahiDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Nicholas P SemenkovichData Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-5266-6734
Janella C SchwabInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3784-9174
Chloe M SachsDivision of Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Faridi QaiumDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Peter K HarrisDivision of Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Qingyuan CaiDepartment of Systems Biology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0009-0000-9391-2305
Andrew J GentlesDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0941-9858
James KnightYale Center for Genome Analysis, Department of Molecular Biophysics and Biochemistry, Institute for Biomolecular Design and Discovery, Yale University, New Haven, CT, USA.
Rondell P GrahamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-8686-4867
Antonietta BacchiocchiDepartment of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
Peter C LucasDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-4880-7172
Ryan C FieldsDepartment of Surgery, University of Rochester School of Medicine, Rochester, NY, USA.
Mario SznolDepartment of Medicine, Division of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-4137-9662
Ruth HalabanDepartment of Dermatology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-8451-1964
David Y ChenDivision of Dermatology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-3681-6576
Aadel A ChaudhuriDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA. Chaudhuri.Aadel@mayo.edu.ORCID http://orcid.org/0000-0003-3115-3061
Aaron M NewmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA. amnewman@stanford.edu.ORCID http://orcid.org/0000-0002-1857-8172
Funding
Yale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI DAVID F STERN · 2006 to 2026
$43.9MDeterminants of toxicity and response to immune checkpoint blockade through integrative profiling of T cell clonal dynamics and plasma cell- free DNAR01CA283317 · NCI · MAYO CLINIC ROCHESTER · PI Aadel Chaudhuri, Aaron M Newman · 2024 to 2026
$3.4MNCI NIH HHS P50 CA121974NCI NIH HHS R01 CA283317
Abstract
Multicellular programs in the tumour microenvironment (TME) drive cancer pathogenesis and response to therapy but remain challenging to identify and profile clinically
Indexed as
MelanomaTumor MicroenvironmentCarcinomaDNA MethylationHumansImmunotherapySpatial Transcriptomics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.