Evidence map›Paper›PMID 42092148›Full record

ArticleNature2026

Prefrontal to ventral tegmental area dynamics drive contingency degradation.

Madelyn M Hjort, Zoe Q Garrett, Adam G Gordon, Ethan Ancell, Marta Trzeciak, Pei-Yun Lu, Michael R Bruchas, Daniela M Witten, Nicholas A Steinmetz, Garret D Stuber

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Madelyn M HjortGraduate Program in Neuroscience, University of Washington, Seattle, WA, USA.
Zoe Q GarrettCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1130-7801
Adam G GordonCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7550-5084
Ethan AncellCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7745-3399
Marta TrzeciakCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.
Pei-Yun LuCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.
Michael R BruchasCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4713-7816
Daniela M WittenCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.
Nicholas A SteinmetzCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7029-2908
Garret D StuberCenter for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA. gstuber@uw.edu.ORCID http://orcid.org/0000-0003-1730-4855

Funding

Neural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5M
NIDA NIH HHS R37 DA032750
6 · The paper itself

Abstract

Cognitive flexibility refers to the adaptive neural processes that adjust learned behaviours as circumstances shift, supporting optimal decision-making and behavioural control. This includes the capacity to modify specific behaviours as the contingency between cues and rewards degrades. Across species

Indexed as

Prefrontal CortexVentral Tegmental AreaAnimalsCognitive FlexibilityCuesLearningMaleMiceModels, NeurologicalNeural PathwaysNeuronsOptogeneticsReward

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.