ArticleNature2026
Androgen loss accelerates brain tumour growth via HPA axis activation.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- A pan-cancer single-cell atlas uncovers the role of sex hormones and chromosomes in sex-divergent reprogramming of the tumor microenvironment.Cell communication and signaling : CCS · 2026Article
- A proteogenomic RNA processing mechanism drives sex differences in meningioma.Research square · 2026Article
- Mechanism and intervention strategy of thymus atrophy in cancer immunotherapy.American journal of cancer research · 2026Review
Corrections and comments
- Update of
Authors and funding
31 authors.
Juyeun LeeDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-8276-5020
Yoon-Mi Chung *Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0001-9721-9444
Daniel J Silver *Department of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-7085-2626
Yue Hao *TGen, Translational Genomics Research Institute, Phoenix, AZ, USA.
Dylan Scott Lykke HarwoodThe Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Alyssa EalyDepartment of Neurosciences, Cleveland Clinic Research, Cleveland, OH, USA.
Amanda M SerapigliaDepartment of Neurosciences, Cleveland Clinic Research, Cleveland, OH, USA.
Lee CurtinMOSAIC (Mathematical Oncology Systems Analysis of Imaging Center), Cedars-Sinai, Los Angeles, CA, USA.
Julia R BenedettiDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Christine Ann Pittman BallardDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Kamya LapsleyDepartment of Neurosciences, Cleveland Clinic Research, Cleveland, OH, USA.
Andrea Alvarez-VazquezDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-8626-8926
Jessica GoldbergDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Cathy LiDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.ORCID http://orcid.org/0009-0002-4924-4439
Sehaj KaurDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Rian NealDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Sabrina Z WangDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Kristen E KayDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Josephine VolovetzDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Ellen S HongDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
R'ay FodorDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Jakub JarmulaDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA.
Michael NicosiaDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH, USA.
Joshua B RubinDepartment of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, MO, USA.
Kristin R SwansonMOSAIC (Mathematical Oncology Systems Analysis of Imaging Center), Cedars-Sinai, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2464-6119
Quinn T OstromDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Nikhil PanickerDepartment of Neurosciences, Cleveland Clinic Research, Cleveland, OH, USA.
Bjarne Winther KristensenThe Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Michael BerensTGen, Translational Genomics Research Institute, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0002-3382-6787
Nima SharifiDesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0003-1281-3474
Justin D LathiaDepartment of Cancer Sciences, Cleveland Clinic Research, Cleveland, OH, USA. lathiaj@ccf.org.ORCID http://orcid.org/0000-0003-3168-7290
Funding
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8MTranslational and Therapeutics CoreP30AG072959 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI JAGAN AYYAPPAN PILLAI · 2021 to 2026
$23.9MSex-specific differences in the tumor microenvironment alter glioblastoma growthP01CA245705 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI Justin D. Lathia · 2020 to 2026
$15.0MOutreach CoreU54CA274504 · NCI · MAYO CLINIC ARIZONA · PI Kristin R Swanson · 2023 to 2026
$8.6MElucidating a novel molecular biomarker for castration-resistant prostate cancerR01CA172382 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Nima Sharifi · 2012 to 2026
$5.2MQuantifying Multiscale Competitive Landscapes of Clonal Diversity in GlioblastomaU01CA220378 · NCI · MAYO CLINIC ARIZONA · PI HU, LELAND, SWANSON, KRISTIN R · 2017 to 2021
$4.3MLangworthy Diversity Supplement: Image-based models of tumor-immune dynamics in glioblastomaU01CA250481 · NCI · MAYO CLINIC ARIZONA · PI CANOLL, PETER, HU, LELAND · 2021 to 2025
$3.8MContribution of Myeloid-Derived Suppressor Cells to Neuro-Inflammatory Alterations and Disease Progression in GlioblastomaR35NS127083 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Justin D. Lathia · 2022 to 2026
$3.1MAberrant tumor metabolism that enables AR antagonist-resistant prostate cancerR01CA236780 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHARIFI, NIMA · 2020 to 2024
$1.8MCYP17A1-independent androgen synthesis and prostate cancer resistance to next-generation hormonal therapyR01CA261995 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Nima Sharifi · 2022 to 2026
$1.8MASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy DementiasR00AG066862 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI PANICKER, NIKHIL · 2022 to 2024
$747kGasdermin-D tags mitochondria to serve as mobile propagators of inflammatory responsesR35GM162199 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI Nikhil Panicker · 2026 to 2026
$432kNCI NIH HHS F31 CA264849NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P01 CA245705NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA172382NCI NIH HHS R01 CA236780NCI NIH HHS R01 CA261995NCI NIH HHS U01 CA220378NCI NIH HHS U01 CA250481NCI NIH HHS U54 CA274504NIA NIH HHS P30 AG072959NIA NIH HHS R00 AG066862NIGMS NIH HHS R35 GM162199NINDS NIH HHS R35 NS127083
Abstract
Many cancers, including glioblastoma (GBM), show a male-biased incidence and associated worse outcomes
Indexed as
AndrogensBrain NeoplasmsGlioblastomaHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemAnimalsCastrationFemaleGlucocorticoidsHumansInflammasomesInterleukin-1betaMaleMiceMice, Inbred C57BLMicrogliaAndrogensGlucocorticoidsInflammasomesInterleukin-1betaTestosteroneTumor Necrosis Factor-alpha
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.