Evidence map›Paper›PMID 42092133›Full record

ArticleNature2026

RNA-triggered cell killing with CRISPR-Cas12a2.

Paul Scholz, Jared Thompson, Kadin T Crosby, Torsten Fauth, Nathan M Krah, Grant Schlauderaff, Robin Back, Zachary A Berkheimer, Alivia Jolley, Dirk Sombroek and 11 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Paul Scholz *Akribion Therapeutics GmbH, Zwingenberg, Germany. paul.scholz@akribion-therapeutics.com.ORCID http://orcid.org/0009-0003-6866-0689
Jared Thompson *Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0009-0006-8557-9702
Kadin T Crosby *Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA.ORCID http://orcid.org/0009-0001-0201-5340
Torsten FauthAkribion Therapeutics GmbH, Zwingenberg, Germany.
Nathan M KrahDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0009-0003-8297-7359
Grant SchlauderaffDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0365-9073
Robin BackAkribion Therapeutics GmbH, Zwingenberg, Germany.ORCID http://orcid.org/0009-0002-1730-7941
Zachary A BerkheimerDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Alivia JolleyDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0009-0005-7520-5494
Dirk SombroekAkribion Therapeutics GmbH, Zwingenberg, Germany.
Rebekka MedertAkribion Therapeutics GmbH, Zwingenberg, Germany.ORCID http://orcid.org/0000-0001-7571-3732
Christian ZurekBRAIN Biotech AG, Zwingenberg, Germany.
Oleg DmytrenkoHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.ORCID http://orcid.org/0000-0002-1165-6836
Emily WilsonDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Friso T SchutHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.
Jared RutterDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-2710-9765
Xiaoyang ZhangDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-0031-0290
Michael KrohnAkribion Therapeutics GmbH, Zwingenberg, Germany.
Ryan N JacksonDepartment of Chemistry and Biochemistry, Utah State University, Logan, UT, USA. ryan.jackson@usu.edu.ORCID http://orcid.org/0000-0001-7403-3794
Chase L BeiselHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@helmholtz-hiri.de.ORCID http://orcid.org/0000-0003-0650-9943
Yang LiuDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. yang.liu@biochem.utah.edu.ORCID http://orcid.org/0000-0002-3889-9707

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
University of Utah Genetics Training ProgramT32GM141848 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GOLIC, KENT G, GRUNWALD, DAVID J. · 2021 to 2025
$2.9M
Determining the Structure and Function of Newly Discovered Immune SystemsR35GM138080 · NIGMS · UTAH STATE UNIVERSITY · PI Ryan Neal Jackson · 2020 to 2026
$2.8M
Mapping the Cellular Responses to DNA Double-Strand Breaks Using On-Demand CRISPR technologies and High-resolution Fluorescence MicroscopyR35GM150941 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Yang Liu · 2023 to 2026
$1.7M
NCI NIH HHS P30 CA042014NIGMS NIH HHS R35 GM138080NIGMS NIH HHS R35 GM150941NIGMS NIH HHS T32 GM141848
6 · The paper itself

Abstract

Selectively eradicating target cells on the basis of their genetic or transcriptional identity remains important in basic research, medicine, biotechnology and agriculture

Indexed as

Cell DeathCRISPR-Associated ProteinsCRISPR-Cas SystemsEndodeoxyribonucleasesGene EditingBacterial ProteinsDNADNA Breaks, Double-StrandedHumansRNASaccharomyces cerevisiaeBacterial ProteinsCas12a proteinCRISPR-Associated ProteinsDNAEndodeoxyribonucleasesRNA

Identifiers

PMID42092133
PMCPMC13323058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.