SynthesisEvidence-based dentistry2026
Efficacy of curcumin in the management of oral submucous fibrosis: an umbrella review.
Synthesis in Evidence-based dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis umbrella review was planned to synthesize pooled evidence on the efficacy of curcumin in alleviating clinical manifestations of OSMF.
methodsThe protocol of this review was registered at the Prospective Register of Systematic Reviews (PROSPERO) and the Joanna Briggs Institute (JBI) guidelines were extensively followed. Multiple databases, including PubMed, Scopus, and Embase, were searched to retrieve relevant literature. Data was extracted using a systematically designed data extraction form. An overlap assessment was performed using the GROOVE Tool. A meta-analysis (using a random effects model) was performed to estimate the overall efficacy of curcumin in managing OSMF conditions. Quality assessment for included studies was also carried out using the Assessment of Multiple Systematic Reviews-2 (AMSTAR 2) tool.
resultsA total of six SR (n = 1) and SRMAs (n = 5) were included in this review. Overlap assessment found a higher level of overlap (19.39%) of primary studies across included studies. Meta-analysis revealed statistically significant results in improving burning sensation within intervention group [standardized mean difference (SMD = -2.66 (95% CI: -3.56 to -1.77); Z-score = 5.83, p-value < 0.001]. However, for other clinical symptoms, results remained statistically non-significant with variable heterogeneity (0% to 95%). A critical appraisal of the included studies demonstrated a high to moderate level (66.66%) of confidence in the overall evidence presented by the included studies.
conclusionFindings suggest that curcumin offers limited benefits while managing OSMF conditions, especially in the early stages. Its optimal role may be as an adjunct in multimodal management strategies rather than a standalone therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.