ReviewCommunications biology2026
Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.
Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
We review Prefrontal-striatum interplay in goal-directed behavior, focusing on prefrontal (PFC) and striatal macro- and micro-domain interactions in hierarchical engagement with goals, strategies and actions. This dual-control framework posits a role for the striatal matrix in engaging with behavioral options- for automatization, and prefrontal modulation of striatal engagement for flexibility. Hierarchical prefronto-basal-ganglia loops incorporating ventral-, dorsomedial-, and dorsolateral striatum represent goals, strategies and actions respectively. The striatal "switchboard" enables engagement, a unified function across macro-domains, while its modulation by PFC operates through dual mechanisms: fast switching via direct matrix inputs, and slower, learning-based adaptation using a striosome-dopamine pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.