Evidence map›Paper›PMID 42092046›Full record

ArticleLeukemia2026

U2af1

Michael O Alberti, Sridhar Nonavinkere Srivatsan, Jin Shao, Dennis L Fei, Mengou Zhu, Claudia Cabrera Pastrana, Monique Chavez, Stefan P Tarnawsky, Sarah Grieb, Timothy A Graubert and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

12 authors.

Michael O AlbertiDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-4269-4701
Sridhar Nonavinkere SrivatsanDepartment of Medicine, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6293-4632
Jin ShaoDepartment of Medicine, Washington University, St. Louis, MO, USA.
Dennis L FeiDepartment of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Mengou ZhuDepartment of Medicine, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-7969-3983
Claudia Cabrera PastranaDepartment of Medicine, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-9748-2020
Monique ChavezDepartment of Medicine, Washington University, St. Louis, MO, USA.
Stefan P TarnawskyDepartment of Medicine, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-7970-702X
Sarah GriebDepartment of Medicine, Washington University, St. Louis, MO, USA.
Timothy A GraubertMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7710-1171
Omar Abdel-WahabMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Matthew J WalterDepartment of Medicine, Washington University, St. Louis, MO, USA. mjwalter@wustl.edu.ORCID http://orcid.org/0000-0002-7753-1091

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Specimen Acquistition and Expression ProfilingP01CA101937 · NCI · WASHINGTON UNIVERSITY · PI PAYTON, JACQUELINE E. · 2003 to 2023
$58.8M
Targeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6M
The Memorial Sloan Kettering Cancer Center SPORE in LeukemiaP50CA254838 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Eytan Stein · 2021 to 2026
$16.8M
Washington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7M
Genetic and molecular basis for SRSF2 mutations in myelodysplasiaR01HL128239 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Omar Abdel-Wahab, Robert K Bradley · 2015 to 2026
$8.0M
Interrogating the minor spliceosome to understand and treat leukemiaR01CA251138 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ABDEL-WAHAB, OMAR, BRADLEY, ROBERT K · 2020 to 2024
$3.3M
Synthetic introns for selective targeting of RNA splicing factor-mutant leukemiaR01CA283364 · NCI · FRED HUTCHINSON CANCER CENTER · PI Omar Abdel-Wahab, Robert K Bradley · 2023 to 2026
$2.9M
Targeting an RNA Binding Protein Network in Acute Myeloid LeukemiaR01CA242020 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ABDEL-WAHAB, OMAR, AIFANTIS, IANNIS · 2020 to 2024
$2.7M
Understanding and Targeting Aberrant RNA Splicing in LeukemiaR35CA304457 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Omar Abdel-Wahab · 2025 to 2026
$2.0M
Leukemia and Lymphoma Society (Leukemia & Lymphoma Society) 7024-21NCATS NIH HHS UL1 TR002345NCI NIH HHS F31 CA284751NCI NIH HHS K12 CA167540NCI NIH HHS P01 CA101937NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA171963NCI NIH HHS P50 CA254838NCI NIH HHS R01 CA242020NCI NIH HHS R01 CA251138NCI NIH HHS R01 CA283364NCI NIH HHS R35 CA304457NHLBI NIH HHS K08 HL159354NHLBI NIH HHS R01 HL128239
6 · The paper itself

Abstract

Recurrent somatic mutations in the spliceosome genes SF3B1, SRSF2, and U2AF1 are frequently identified in patients with myeloid neoplasms, such as myelodysplastic syndromes. We characterized the in vivo consequences of expressing two hotspot mutations in U2AF1 that code for the S34F and Q157R substitutions. Our results indicate that the two mutations induce distinct hematopoietic phenotypes in mice, suggesting that the U2AF1

Indexed as

HematopoiesisMutationMyelodysplastic SyndromesSplicing Factor U2AFAnimalsHumansMicePhenotypeSerine-Arginine Splicing FactorsSerine-Arginine Splicing FactorsSplicing Factor U2AFU2AF1 protein, humanZrsr1 protein, mouse

Identifiers

PMID42092046
PMCPMC13276503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.