Evidence map›Paper›PMID 42091990›Full record

Trial reportScientific reports2026

Association between FTO rs9939609 genotype and breast cancer risk after bariatric surgery in the Swedish Obese Subjects study.

Elin Langegård, Felipe M Kristensson, Johanna C Andersson-Assarsson, Markku Peltonen, Per-Arne Svensson, Peter Jacobson, Sofie Ahlin, Kajsa Sjöholm, Lena M S Carlsson, Magdalena Taube

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01479452 (Effects of Bariatric Surgery in Swedish Obese Subjects), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01479452 nacompletednot on this map

Effects of Bariatric Surgery in Swedish Obese Subjects

TypeinterventionalSponsorGöteborg UniversityRan1987 to 2005Enrolled4,047ConditionsObesityArmsBariatric surgery, Usual care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elin Langegård *Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Felipe M Kristensson *Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Johanna C Andersson-AssarssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Markku PeltonenFinnish Institute for Health and Welfare, Helsinki, Finland.
Per-Arne SvenssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Peter JacobsonDepartment of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Sofie AhlinDepartment of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Kajsa SjöholmDepartment of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Lena M S CarlssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden.
Magdalena TaubeDepartment of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, SOS Sekretariatet, Vita Stråket 15, 413 45, Gothenburg, Sweden. magdalena.taube@gu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The FTO rs9939609 SNP has been linked to higher BMI, insulin resistance, and breast cancer risk. Weight loss by bariatric surgery lowers breast cancer risk, particularly in women with baseline hyperinsulinemia, but it is unclear whether this effect varies by FTO genotype. In the Swedish Obese Subjects (SOS) study, 2596 women with severe obesity were followed for a median of 23.9 years to examine breast cancer incidence after bariatric surgery compared with usual care. Genotyping for rs9939609 was performed, and breast cancer events were identified via the Swedish National Cancer Registry. Among 135 breast cancer cases (77 in the control group and 58 in the surgery group), surgery was associated with a lower breast cancer incidence in carriers of the risk allele (TA/AA) (adjusted HR = 0.53 [0.34-0.83], P = 0.005), but not in non-carriers (TT) (adjusted HR = 1.19 [0.65-2.15], P = 0.573; P for treatment-genotype interaction = 0.031). These findings suggest that the FTO rs9939609 genotype may modify the association between bariatric surgery and breast cancer incidence. Trial registration: ClinicalTrials.gov, identifier: NCT01479452.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOBariatric SurgeryBreast NeoplasmsObesityPolymorphism, Single NucleotideAdultFemaleGenetic Predisposition to DiseaseGenotypeHumansIncidenceMiddle AgedRisk FactorsSwedenAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanBreast cancerFat mass and obesity associated protein (FTO)InsulinObesity

Identifiers

PMID42091990
PMCPMC13149690

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.