Evidence map›Paper›PMID 42091889›Full record

ArticleNature communications2026

Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging.

Zhuoning Miao, Ziyang Tong, Linjing Shi, Yang Fei, Tao Zhang, Chunmei Fan, Tian Qin, Jia Gao, Qiangqiang Zheng, Xianan Mo and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhuoning Miao *Department of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.
Ziyang Tong *Department of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.
Linjing Shi *Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yang FeiDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.
Tao ZhangDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.ORCID http://orcid.org/0000-0001-6742-7939
Chunmei FanDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.
Tian QinDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China.
Jia GaoDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.
Qiangqiang ZhengDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.
Xianan MoDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.ORCID http://orcid.org/0009-0004-0572-6238
Hongwei OuyangDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China.ORCID http://orcid.org/0000-0003-0627-2536
Zi YinDr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, PR China. yinzi@zju.edu.cn.ORCID http://orcid.org/0000-0003-2892-8962
Ren XuICMRS Collaborating Center for Skeletal Stem Cells, State Key Laboratory of Cellular Stress Biology, The First Affiliated Hospital of Xiamen University, Faculty of Medicine and Life Sciences, School of Medicine, Xiamen University, Xiamen, China. xuren526@xmu.edu.cn.ORCID http://orcid.org/0000-0001-6578-4553
Yiting ZhouDr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, PR China. zhouyt@zju.edu.cn.ORCID http://orcid.org/0000-0003-4543-3099
Xiao ChenDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, PR China. chenxiao-610@zju.edu.cn.ORCID http://orcid.org/0000-0002-4438-5286

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aging process exhibits tissue-specific characteristics, yet its underlying mechanisms remain poorly understood. While it is widely accepted that a reduction in blood vessels in hard tissues contributes to aging, such as in osteoporosis, the vascular changes driving soft tissue aging and degeneration remain unclear. Here, by integrating single-cell transcriptomics and light-sheet imaging, we uncover a striking infiltration of type H-like blood vessels and an aging-specific Coch

Indexed as

AgingBlood VesselsAnimalsCell DifferentiationChemokine CXCL12FemaleMaleMiceMice, Inbred C57BLSignal TransductionStem CellsTamoxifenVascular Endothelial Growth Factor AChemokine CXCL12Cxcl12 protein, mouseTamoxifenVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouse

Identifiers

PMID42091889
PMCPMC13357837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.