Evidence map›Paper›PMID 42091878›Full record

ArticleNature communications2026

Selective positive allosteric modulation of β

Edgardo J Sánchez Rivas, Fredrik Sadler, Mohammadamin Safdari, Nishaben M Patel, Michael Ritt, Ning Ma, Sergio Branciamore, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Edgardo J Sánchez Rivas *Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0002-6456-3676
Fredrik Sadler *Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Mohammadamin SafdariDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Monrovia, California, USA.
Nishaben M PatelDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0003-4724-5710
Michael RittDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Ning MaDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Monrovia, California, USA.ORCID http://orcid.org/0000-0003-4653-7797
Sergio BranciamoreDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Monrovia, California, USA.ORCID http://orcid.org/0000-0002-2556-8765
Nagarajan VaidehiDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Monrovia, California, USA.ORCID http://orcid.org/0000-0001-8100-8132
Sivaraj SivaramakrishnanDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA. sivaraj@umn.edu.ORCID http://orcid.org/0000-0002-9541-6994

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Emergent cellular functions of GPCRs and myosinsR35GM126940 · NIGMS · UNIVERSITY OF MINNESOTA · PI Sivaraj Sivaramakrishnan · 2018 to 2026
$3.8M
An integrated toolkit combining computational systems biology techniques with molecular dynamics simulations to delineate functionality of GPCRsR01LM013876 · NLM · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RODIN, ANDREI, VAIDEHI, NAGARAJAN · 2022 to 2025
$1.5M
Emergent role of allostery on function of GPCRs and Trimeric G proteinsR35GM156498 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Nagarajan Vaidehi · 2025 to 2026
$890k
NIAMS NIH HHS T32 AR007612NIGMS NIH HHS R35 GM126940NIGMS NIH HHS R35 GM156498NLM NIH HHS R01 LM013876U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) T32-AR007612U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM126940U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM156498U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM) R01-LM013876
6 · The paper itself

Abstract

GPCR therapeutics primarily target structured cavities formed by the seven transmembrane α-helices. However, amino acid sequence conservation in structured regions, especially among receptor subtypes, limits target selectivity. Here, we leverage the sequence divergence of the third intracellular loop (ICL3) of the receptor fold to derive a selective positive allosteric modulator for the β

Indexed as

Receptors, Adrenergic, beta-2Single-Chain AntibodiesAllosteric RegulationAmino Acid SequenceAnimalsAntibodies, MonoclonalCyclic AMPHEK293 CellsHumansProtein BindingSignal TransductionAntibodies, MonoclonalCyclic AMPReceptors, Adrenergic, beta-2Single-Chain Antibodies

Identifiers

PMID42091878
PMCPMC13358155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.