ArticleNature communications2026
Vacuolar iron transporters mediate resistance to triadimefon in plant pathogenic fungi.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Triadimefon resistance in Puccinia striiformis f. sp. tritici (Pst), the fungal pathogen of wheat stripe rust, is increasingly observed in China, but the mechanisms beyond cytochrome P450 14α-demethylase (Cyp51) mutations remain unknown. Through bulked segregant analysis and RNA-seq of a sexual Pst population, we identify three vacuolar iron transporter genes (CCC1), PstCCC1.1, PstCCC1.2 and PstCCC1.3, as key triadimefon sensitivity determinants. Functional analyses show that RNAi-mediated silencing of these genes reduce fungicide resistance, while heterologous expression of natural mutants (PstCCC1.2
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