Evidence map›Paper›PMID 42091876›Full record

ArticleCell death & disease2026

Six1 haploinsufficiency is associated with activation of NF-κB and TNF-related transcriptional signatures in aging mice.

Tianxu Guo, Han Liu, Junjun Ma, Huanyu Yan, Yanglin Chen, Lihua Zhao, Xiyun Guo, Limin Lv, Yixi Wang, Linxin Cheng and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tianxu Guo *Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Han Liu *Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Junjun MaJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Huanyu YanState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Yanglin ChenThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010070, China.
Lihua ZhaoJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Xiyun GuoJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Limin LvLaboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Yixi WangLaboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Linxin ChengJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Guang YangJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Yu ZhangJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Jinbo YuJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.
Xi WangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.ORCID http://orcid.org/0000-0002-7572-6354
Shuguang DuoLaboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. duoshuguang@ioz.ac.cn.
Xihe LiThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010070, China. lixh@imu.edu.cn.ORCID http://orcid.org/0000-0002-7001-7997
Rongfeng LiJiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China. lirongfeng@njmu.edu.cn.ORCID http://orcid.org/0000-0002-9624-3706

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31971379
6 · The paper itself

Abstract

The Six1 (SIX homeobox 1) gene is pivotal in renal and pulmonary development and differentiation. Its dysregulation is implicated in oncogenesis and tumor progression via enhancing cell proliferation and delaying senescence. However, whether or how it functions in the natural aging have not been investigated. To answer this question, we generated Six1 gene knockout mice using CRISPR-Cas9 technology. All Six1 biallelic knockout mice died at birth since the underdeveloped lungs. In Six1

Indexed as

AgingHaploinsufficiencyHomeodomain ProteinsNF-kappa BTumor Necrosis Factor-alphaAnimalsKidneyLungMiceMice, KnockoutSignal TransductionTranscription, GeneticTranscriptomeHomeodomain ProteinsNF-kappa BSix1 protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID42091876
PMCPMC13315602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.