Evidence map›Paper›PMID 42091854›Full record

ArticleCell death & disease2026

mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.

Feiyang Cai, Fan Huang, Christophe Goncalves, Harinee Srikannan, Natascha Gagnon, Elizabeth M Guettler, Léa Mukeba-Harchies, Jennifer Maxwell, Jie Su, Krikor Bijian and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Feiyang CaiDivision of Clinical and Translational Research, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-9977-4190
Fan HuangDivision of Clinical and Translational Research, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3850-5317
Christophe GoncalvesLady Davis Institute, McGill University, Montreal, QC, Canada.
Harinee SrikannanLady Davis Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0009-0001-7585-1593
Natascha GagnonLady Davis Institute, McGill University, Montreal, QC, Canada.
Elizabeth M GuettlerLady Davis Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-0176-9407
Léa Mukeba-HarchiesCancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium.
Jennifer MaxwellDivision of Clinical and Translational Research, McGill University, Montreal, QC, Canada.
Jie SuLady Davis Institute, McGill University, Montreal, QC, Canada.
Krikor BijianLady Davis Institute, McGill University, Montreal, QC, Canada.
Fabrice JourneCancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium.
April A N RoseDivision of Clinical and Translational Research, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-9845-4603
Alexandre OrthweinDepartment of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Sonia Victoria Del RincónDivision of Clinical and Translational Research, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.ORCID http://orcid.org/0000-0002-6350-0227
Wilson H MillerDivision of Clinical and Translational Research, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-180379Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-183934
6 · The paper itself

Abstract

BRAF V600 inhibitors are clinically approved for the treatment of BRAF

Indexed as

Activating Transcription Factor 4MelanomaMTOR InhibitorsProtein Kinase InhibitorsTOR Serine-Threonine KinasesAminohydrolasesAnimalsAzetidinesCell Line, TumorHumansMethylenetetrahydrofolate Dehydrogenase (NADP)MiceMultifunctional EnzymesPiperidinesSignal TransductionActivating Transcription Factor 4AminohydrolasesATF4 protein, humanAzetidinescobimetinibMethylenetetrahydrofolate Dehydrogenase (NADP)MTHFD2 protein, humanMTOR InhibitorsMultifunctional EnzymesPiperidinesProtein Kinase InhibitorsTOR Serine-Threonine Kinases

Identifiers

PMID42091854
PMCPMC13315934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.