ArticleIrish journal of medical science2026
Clinical predictors of persistence in IgE-mediated cow's milk allergy in children with multiple food allergies.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to identify independent clinical predictors of failure to develop tolerance to IgE-mediated cow's milk allergy in children with multiple food allergies.
methodThis retrospective cohort study included 134 children diagnosed with IgE-mediated cow's milk allergy with multiple food allergies. Patients were divided into two groups based on tolerance development: those who developed tolerance and those who did not. Demographic characteristics, clinical findings after food intake, and laboratory parameters were compared between groups. To identify independent clinical risk factors associated with the lack of tolerance development, clinical variables found to be statistically significant (p < 0.05) in univariate analyses were included in multivariate logistic regression analysis.
resultsNinety-six patients (71.6%) were male, with a median age of 84 months (range: 33-146 months). The median age at symptom onset was 5 months (range: 1-36 months), and the median follow-up duration was 79 months (range: 1-93 months). Atopic eczema was present in 42.5% of patients, and a history of recurrent wheezing or asthma was present in 14.2%. Among concomitant food allergies, egg allergy was the most common (50.7%). While cutaneous findings were most frequently observed in initial reactions, wheezing (18.7%) was the most common respiratory symptom. Anaphylaxis was diagnosed in 24.6% of patients. In the multivariate logistic regression analysis performed to determine the clinical risk factors associated with the failure to develop tolerance to IgE-mediated cow's milk allergy in patients, the following factors were identified: as the initial reaction after cow's milk intake are anaphylaxis [OR: 4.95 (1.82-13.5), p = 0.002], hypotension [OR: 3.97 (1.19-13.2), p = 0.025)], wheezing [OR: 2.86 (1.11-7.36), p = 0.029] and lethargy [OR: 3.53 (1.23-10.1), p = 0.019)] were identified as independent risk factors.
conclusionSevere clinical reactions initially presenting with systemic and respiratory involvement are independent clinical predictors of failure to develop tolerance to IgE-mediated cow's milk allergy in children with multiple food allergies.
Indexed as
Identifiers
42091841What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.