ArticleDrug delivery and translational research2026
A design of experiments study of nasal spray deposition in the alberta idealized nasal inlet.
Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intranasal administration of drugs possesses numerous advantages such as easy and direct application, rapid onset of action and reduced risk of systemic adverse effects. The nasal cavity consists of several regions and especially the respiratory region, known as the turbinates, is considered favorable for drug uptake. Current Food and Drug Administration (FDA) guidelines for in vitro testing of nasal spray formulations recommend characterization of emitted dose, plume geometry, spray pattern, and particle size distribution. However, recommendations or guidelines for assessing regional deposition within the nasal cavity remain lacking. In this study, we used the Alberta Idealized Nasal Inlet for in vitro testing and a design of experiments (DoE) approach to test the regional deposition of a commercially available nasal spray Otrivin
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