Evidence map›Paper›PMID 42091758›Full record

ArticleCellular and molecular neurobiology2026

Spinal Cord Stimulation Alleviates Neuropathic Pain Involves Regulation of the Ca

Xiangmiao Li, Zhen Wu, Rongrong Wang, Jinzhu Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiangmiao LiSchool of Rehabilitation, Capital Medical University, 10 Jiaomen North Road, Fengtai District, Beijing, 100068, China.ORCID https://orcid.org/0009-0005-5796-3195
Zhen WuBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, No. 6 Beiertiao, Beijing, 100190, China.ORCID https://orcid.org/0009-0009-3321-7330
Rongrong WangDepartment of Rehabilitation Medicine, Henan Provincial People's Hospital, No. 7, Weiwu Road, Jinshui District, Zhengzhou, 463599, China.ORCID https://orcid.org/0009-0004-3242-3961
Jinzhu BaiSchool of Rehabilitation, Capital Medical University, 10 Jiaomen North Road, Fengtai District, Beijing, 100068, China. baijinzhu@126.com.ORCID https://orcid.org/0000-0003-2284-782X

Funding

Beijing Science and Technology Planning Project Z241100007724002
6 · The paper itself

Abstract

Spinal cord stimulation (SCS) represents an established neuromodulatory intervention for refractory neuropathic pain (NP), yet the cellular mechanisms underlying its anti-inflammatory effects remain incompletely defined. The activation of astrocytes, especially polarization into the A1-like phenotype, is crucial for the persistence of central sensitization. This study aimed to investigate whether the analgesic effects of SCS are associated with modulation of astrocyte activation and calcium ions (Ca

Indexed as

AstrocytesCalcineurinCalciumNeuralgiaNFATC Transcription FactorsSpinal Cord Dorsal HornSpinal Cord StimulationAnimalsHyperalgesiaMaleNerve Tissue ProteinsRatsRats, Sprague-DawleySignal TransductionCalcineurinCalciumNerve Tissue ProteinsNfatc4 protein, ratNFATC Transcription FactorsAstrocyteCalcineurinNeuroinflammationNeuropathic painNFAT4Spinal cord stimulation

Identifiers

PMID42091758
PMCPMC13315078

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.