Evidence map›Paper›PMID 42091727›Full record

ArticleApplied microbiology and biotechnology2026

Motility and growth Burkholderia two-component: a new regulatory system of Burkholderia seminalis.

Juliana Cardinali-Rezende, Carolina A P T Silva, Alessandra Costa, Leandro M Garrido, Milene Ferro, Mauricio Bacci, Ana Olivia De Souza, Welington Luiz Araújo

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In one paragraph

Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juliana Cardinali-RezendeLGEM - Laboratory of Genetics and Metabolic Engineering, Center for Natural and Human Sciences, Federal University of ABC, Av Dos Estados, 5001 - Bl A - Tw 3 - Room 651-3 -Lab. L204-B, Santo André, SP, CEP 09210-580, Brazil. j.cardinali@ufabc.edu.br.
Carolina A P T SilvaLABMEM, Department of Microbiology, Institute of Biomedical Sciences, Biomedical Building II (ICB-2), University of São Paulo, Av. Lineu Prestes, 1374 - Butantã, São Paulo, SP, 05508-900, Brazil.
Alessandra CostaLABMEM, Department of Microbiology, Institute of Biomedical Sciences, Biomedical Building II (ICB-2), University of São Paulo, Av. Lineu Prestes, 1374 - Butantã, São Paulo, SP, 05508-900, Brazil.
Leandro M GarridoLABMEM, Department of Microbiology, Institute of Biomedical Sciences, Biomedical Building II (ICB-2), University of São Paulo, Av. Lineu Prestes, 1374 - Butantã, São Paulo, SP, 05508-900, Brazil.
Milene FerroInstitute of Bioscience of Rio Claro, Paulista State University of Júlio de Mesquita Filho, Rio Claro, Brazil.
Mauricio BacciInstitute of Bioscience of Rio Claro, Paulista State University of Júlio de Mesquita Filho, Rio Claro, Brazil.
Ana Olivia De SouzaMolecular Biology Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Welington Luiz AraújoLABMEM, Department of Microbiology, Institute of Biomedical Sciences, Biomedical Building II (ICB-2), University of São Paulo, Av. Lineu Prestes, 1374 - Butantã, São Paulo, SP, 05508-900, Brazil. wlaraujo@usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The two-component regulatory system (TCS) is a highly conserved global signal transduction mechanism that enables microorganisms to adapt to changing environments in response to signals. Burkholderia seminalis TC3.4.2R3 has attracted attention as a potential phytopathogenic biological control agent. In this study, a TCS mutant was obtained and evaluated in comparison to wild type using different approaches. The transcriptome analysis revealed 374 differentially expressed genes, some of which are involved in motility and chemotaxis (downregulated) and related to iron uptake and pyochelin production (upregulated). Swarming and swimming motility were impaired in the mutant, while biofilm production increased, leading to differences in growth profiles. However, the biocontrol efficacy was similar. These findings suggest that the new TCS, named motility and growth Burkholderia two-component regulator (MgbTC), positively regulates motility and chemotaxis genes while negatively controlling genes related to biofilm production, iron uptake and pyochelin siderophore production in the Burkholderia seminalis TC3.4.2R3. KEY POINTS: • The new motility and growth of Burkholderia two-component regulator (MgbTC) system • MgbTC positively regulates motility and chemotaxis genes in B. seminalis TC3.4.2R3 • MgbTC negatively controls iron uptake and pyochelin and biofilm production genes.

Indexed as

BurkholderiaGene Expression Regulation, BacterialBacterial ProteinsBiofilmsChemotaxisGene Expression ProfilingIronMutationPhenolsSignal TransductionThiazolesBacterial ProteinsIronPhenolspyochelinThiazolesBiofilm formationBurkholderia seminalisMotility and chemotaxisPyochelin productionRNASeqTwo-component regulatory system

Identifiers

PMID42091727
PMCPMC13197385

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.