Evidence map›Paper›PMID 42091715›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Acquired spontaneous periodic hypothermia and pancytopenia secondary to hypothalamic compression from a large skull base meningioma.

Sagar Jolly, Bilal Ali, Rishabh Jain, Shashank Paliwal, Sreerashmi Sasikumar, Delatre Lolo

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Sagar JollyDepartment of Anesthesiology, New York Medical College, Metropolitan Hospital Center, 1901 1st Ave, New York, NY, 10029, USA. medsagar10@gmail.com.ORCID http://orcid.org/0009-0008-5836-6714
Bilal AliDepartment of Anesthesiology, New York Medical College, Metropolitan Hospital Center, 1901 1st Ave, New York, NY, 10029, USA.
Rishabh JainDepartment of Interventional Radiology, Fortis Escorts Heart Institute, Okhla, New Delhi, India.
Shashank PaliwalDepartment of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, Bathinda, Punjab, India.
Sreerashmi SasikumarDepartment of Internal Medicine, New York Medical College, Metropolitan Hospital Center, New York, USA.
Delatre LoloDepartment of Internal Medicine, New York Medical College, Metropolitan Hospital Center, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 69-year-old woman with a recurrent skull-base meningioma developed recurrent hypothermia during rehabilitation, initially misattributed to infection. Episodes followed a circadian pattern and were associated with delirium, pancytopenia, and signs of central endocrine dysfunction. MRI showed a large meningioma compressing the hypothalamus with an intact corpus callosum. Infection and adrenal insufficiency were excluded. Hypothermia resolved with external warming, and pancytopenia normalized spontaneously. Subclinical hypothyroidism and central hypogonadism were noted, consistent with hypothalamic-pituitary axis involvement. These findings supported a diagnosis of acquired spontaneous periodic hypothermia (SPH) due to hypothalamic compression. This case illustrates that early recognition of SPH in patients with skull-base tumors can prevent misdiagnosis and guide appropriate supportive care and monitoring.

Indexed as

Hypothalamic DiseasesHypothalamusHypothermiaMeningeal NeoplasmsMeningiomaPancytopeniaSkull Base NeoplasmsAgedFemaleHumansMagnetic Resonance ImagingHypothalamic dysfunctionNeuroendocrine dysfunctionPancytopeniaSkull base meningiomaSpontaneous periodic hypothermia

Identifiers

PMID42091715
PMCPMC13149600

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