Evidence map›Paper›PMID 42091606›Full record

ArticleNPJ science of food2026

The association of time-restricted eating and indices of organ-specific aging in relation to metabolic health and obesity.

Liuzexuan Sheng, Enze Li, Hongwei Ji, Susan Cheng, Alan Kwan, Evelyne Bischof, Yifan Chen, Jun Pu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liuzexuan Sheng *Division of Cardiology, State Key Laboratory for Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Enze Li *Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Hongwei Ji *Tsinghua Medicine, Tsinghua University, Beijing, China.
Susan ChengDepartment of Cardiology Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alan KwanDepartment of Cardiology Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Evelyne BischofSheba Longevity Department, Tel Aviv University, Tel Aviv, Israel. bischofevelyne@gmail.com.
Yifan ChenDivision of Cardiology, State Key Laboratory for Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. yifanchen@sjtu.edu.cn.
Jun PuDivision of Cardiology, State Key Laboratory for Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. pujun310@sjtu.edu.cn.

Funding

Medical-Engineering Joint Funds of Shanghai Jiao Tong University YG2022QN107National High Level Hospital Clinical Research Funding 2022-PUMCH-C-023National Key Research and Development Program of China 2021YFC2502300National Natural Science Foundation of China 82421001National Science Fund for Distinguished Young Scholars 81625002Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0503204Pudong New District Health Commission PW2023E-02Science and Technology Commission of Shanghai Municipality 22JC1402100Shanghai Institutions of Higher Learning, Innovative Research Team of High-Level Local Universities in Shanghai 2021-01-07-00-02-E00083Shanghai Key Laboratory of Carbohydrate Drugs 19DZ2230300Shanghai Municipal Education Commission SHSMU-ZDCX20210700Shanghai Municipal Health Commission 2022JC013
6 · The paper itself

Abstract

This cross-sectional study explored how time-restricted eating (TRE) interacts with metabolic health and obesity (MH&O) in relation to biological age indices of different organs. Data from the National Health and Nutrition Examination Survey (2003-2018) were analyzed, including 4890 participants. TRE strategies were assessed based on eating frequency and meal timing. Indices of organ-specific biological age (heart, kidney, liver, overall), frailty index, life's essential 8, and cardiometabolic index were evaluated. Metabolic dysfunction and obesity were associated with elevated indices of organ-specific biological age and impaired cardiovascular health, with MU status related to more rapid advancement of cardiovascular biological age indices. Excessively long or short fasting durations were associated with a decline in indices of liver metabolic health and worsened cardiovascular risk markers. Moderate eating frequencies and fasting durations were associated with lower biological age indices and better health metrics across subgroups. The association between better cardiovascular health and healthy metabolism was more pronounced in individuals who ate breakfast on time. This study underscores the independent relationship of MU&O with advancement in indices of organ-specific biological age and impaired cardiovascular health metrics. It also highlights the potential role of personalized TRE in relation to modulated biological age indices across various MH&O statuses.

Identifiers

PMID42091606
PMCPMC13350904

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.