Allergic disease as a risk factor for Parkinson's disease: a possible role of eosinophil.

Hee Jin Chang, Su Hyeon Ha, So-Hee Lee, Seungmin Lee, Chanhee Jeong, Jung Hwan Shin, Han-Joon Kim, Heung-Woo Park

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Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Hee Jin ChangDepartment of Neurology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.

Su Hyeon HaDepartment of Neurology and Movement Disorder Center, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Korea.

So-Hee LeeSeoul National University Hospital, Healthcare System Gangnam Center, Healthcare Research Institute, Seoul, Korea.

Seungmin LeeDepartment of Neurology and Movement Disorder Center, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Korea.

Chanhee JeongDepartment of Neurology and Movement Disorder Center, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Korea.

Jung Hwan ShinDepartment of Neurology and Movement Disorder Center, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Korea.

Han-Joon KimDepartment of Neurology and Movement Disorder Center, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Korea. movement@snu.ac.kr.

Heung-Woo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. guinea71@snu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is central to Parkinson's disease (PD) pathogenesis and allergic inflammation may contribute to PD risk, but evidence is limited. Using the Korean National Health Insurance Service database, we conducted a cohort study of 5,036,518 adults aged ≥40 years who underwent health examination in 2009 and identified incident PD from 2010 to 2019, excluding prior PD. Asthma, allergic rhinitis, and atopic dermatitis were defined by ICD-10 codes and healthcare utilization, and severity by annual outpatient visits. Cox proportional hazards models estimated hazard ratios (HRs) adjusting for demographics, lifestyle, and comorbidities. We compared eosinophil and neutrophil counts between 234 hospital-based PD patients and 468 controls. During follow-up, 44,621 PD cases occurred (0.9/1000 person-years). PD incidence was increased in asthma (HR 1.16; 95% CI 1.07-1.24) and allergic rhinitis (HR 1.18; 95% CI 1.14-1.22), but not atopic dermatitis. Risk increased with multiple allergic conditions (p

Identifiers

PMID42091590

DOI10.1038/s41531-026-01377-w

PMCPMC13358130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.