ReviewJournal of Parkinson's disease2026
Clinical GDNF delivery methods for Parkinson's disease.
Review in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracerebral delivery of glial cell line-derived neurotrophic factor (GDNF) therapeutics continues to show promise, especially in Parkinson's disease (PD). However, randomized, placebo-controlled clinical trials using GDNF protein have been inconclusive to date. A major sham-surgery controlled trial using GDNF gene therapy commenced in 2024. In this review we aim to update the reader on the evolution and current state of the art of intracerebral delivery methods for GDNF protein and gene therapy in PD clinical trials. Our intent is to increase the awareness for the importance, subtleties, and pitfalls of intracerebral delivery when reviewing current available results for these therapies and their prospects going forward. We will compare and contrast GDNF protein infusion versus gene therapy strategies and define specific anatomical and physiological details in trial participants that continue to challenge clinicians and investigators attempting to maximize therapeutic coverage of the target putamen. Despite a growing consensus that convection-enhanced delivery (CED) is the optimal intracerebral infusion strategy for localized administration of therapeutics in general and gene therapy products in particular, there is less agreement on the need for related methods, such as the co-infusion of a gadolinium contrast agent and use of intraoperative magnetic resonance imaging (iMRI) to visualize the therapeutic distribution for optimizing target coverage. Whereas certain debates will continue, most investigators and clinicians respond positively to well-designed trials providing clean, conclusive results. Information included in this review is intended to provide additional insights to interested readers, allowing better assessment of details associated with upcoming GDNF therapeutic investigations.Plain language summary titleClinical Delivery Methods for Treatments Based on Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Parkinson's Disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.