Evidence map›Paper›PMID 42091552›Full record

ArticleInternal medicine (Tokyo, Japan)2026

A Fatal Case of AIDS Complicated by Kaposi's Sarcoma-associated Inflammatory Cytokine Syndrome (KICS).

Tomohiro Tanaka, Masaki Tominaga, Kenji Tsumura, Yoshihisa Tokunaga, Rumi Minami, Masanobu Matsuoka, Saeko Tokisawa, Tomotaka Kawayama, Tomoaki Hoshino, Teja Potluri

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tomohiro TanakaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Masaki TominagaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Kenji TsumuraDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Yoshihisa TokunagaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Rumi MinamiDepartment of Immunology and Infectious Diseases, Clinical Research Institute, NHO Kyushu Medical Center, Japan.
Masanobu MatsuokaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Saeko TokisawaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Tomotaka KawayamaDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Tomoaki HoshinoDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Teja PotluriSchool of Clinical Medicine, University of Cambridge, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 40-year-old man with acquired immunodeficiency syndrome (AIDS) presented with severe thrombocytopenia and disseminated Kaposi's sarcoma (KS). Initially diagnosed with immune thrombocytopenic purpura (ITP), he was treated with corticosteroids and antiretroviral therapy; however, his condition worsened. He met the criteria for Kaposi's sarcoma-associated inflammatory cytokine syndrome (KICS) and received liposomal doxorubicin, showing temporary improvement. KS progression was observed after immune recovery, suggesting KS-associated immune reconstitution inflammatory syndrome. Rituximab was administered, but the patient deteriorated and died. This case highlights the difficulty in distinguishing KICS from ITP, and the importance of an early diagnosis and multidisciplinary care in advanced AIDS.

Indexed as

Acquired Immunodeficiency SyndromeCytokine Release SyndromeImmune Reconstitution Inflammatory SyndromeSarcoma, KaposiAdultCytokinesDoxorubicinFatal OutcomeHumansMaleCytokinesDoxorubicinhuman herpesvirus 8 (HHV-8)Kaposi's sarcomaKaposi's sarcoma-associated inflammatory cytokine syndrome (KICS)Kaposi's sarcoma-immune reconstitution inflammatory syndrome (KS-IRIS)

Identifiers

PMID42091552
PMCPMC13222690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.