Evidence map›Paper›PMID 42091523›Full record

ReviewThe Journal of reproduction and development2026

Preimplantation culture conditions and later-life outcomes: implications for evaluating embryo culture media.

Jannatul Ferdous Jharna, Md Wasim Bari, Sakino Furusato, Kaname Sato, Yui Maruhashi, Norermi Firzana Alfian, Masahiro Horizoe, Yoshiya Morishita, Kei Uechi, Satoshi Kishigami

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of reproduction and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jannatul Ferdous JharnaDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Md Wasim BariFaculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Sakino FurusatoDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Kaname SatoDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Yui MaruhashiDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Norermi Firzana AlfianDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Masahiro HorizoeDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Yoshiya MorishitaDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Kei UechiDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.
Satoshi KishigamiDepartment of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental conditions during early development are critical determinants of lifelong health, as described by the Developmental Origins of Health and Disease (DOHaD) concept. Preimplantation embryos develop entirely within artificial culture systems during assisted reproduction, yet current media are primarily evaluated by short-term developmental outcomes. Accumulating evidence indicates that embryos cultured in vitro differ from in vivo embryos at metabolic and molecular levels and that altered early nutrition can program long-term phenotypes. Here, we discuss how culture medium composition influences embryonic cellular physiology, focusing on nucleolar organization as an indicator of cellular stress. We propose that embryo culture media should be reconsidered using physiological indices linked to long-term safety rather than developmental performance alone.

Indexed as

BlastocystCulture MediaEmbryo Culture TechniquesEmbryonic DevelopmentAnimalsDevelopmental Origins of Health and DiseaseFemaleHumansPregnancyCulture MediaDevelopmental outcomesEmbryo cultureNucleolar morphologyPreimplantation development

Identifiers

PMID42091523
PMCPMC13441458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.