ArticleOsong public health and research perspectives2026
The clonality and dissemination of carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital in Malaysia: a retrospective analysis from 2022 to 2023.
Article in Osong public health and research perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundCases of nosocomial carbapenem-resistant Klebsiella pneumoniae (CRKP) have been increasing steadily since the 1990s. In this study, we sought to assess CRKP clonal diversity and patterns of dissemination at Hospital Canselor Tuanku Muhriz (HCTM), a tertiary university hospital located in Kuala Lumpur, Malaysia.
methodsFrom January 2022 to December 2023, all CRKP isolates from HCTM were included in the investigation. Associated patient demographic data and clinical histories were retrieved from hospital records. Antibiotic susceptibility data for the collected isolates were obtained from the HCTM diagnostic laboratory. Molecular typing was performed using enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) to identify genetic clusters. Based on ERIC-PCR clustering results and epidemiological investigations, selected CRKP isolates were subjected to whole-genome sequencing (WGS) to validate clonal relatedness, identify antimicrobial resistance genes, and establish phylogenomic relationships.
resultsDuring the study period, a total of 147 CRKP isolates were recovered from various wards across HCTM. All isolates exhibited resistance to imipenem, meropenem, or ertapenem, with 124 isolates confirmed as carbapenemase producers. ERIC-PCR identified 24 genetic clusters disseminated across 23 wards within HCTM. Twelve CRKP isolates were selected for WGS based on integrated epidemiological investigation and ERIC-PCR genotyping; sequence typing revealed ST17 as the dominant circulating CRKP lineage in the intensive care unit, ward 6E, and possibly across the hospital. The carbapenemase gene bla_NDM was detected in all WGS-analyzed CRKP isolates.
conclusionIntegrating epidemiological investigation, phenotypic testing, molecular typing, and WGS is essential to understand resistance dynamics, map transmission, and guide hospital infection prevention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.