Evidence map›Paper›PMID 42090845›Full record

ArticleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2026

Development and validation of UHPLC-MS/MS methods for determination of piperaquine in quantitative dried blood samples and microvolume plasma samples.

Meiyun Serena He, Sindy He, Michelle Roh, Abel Kakuru, Prasanna Jagannathan, Grant Dorsey, Philip Rosenthal, Francesca Aweeka, Liusheng Huang

Abstract read
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In one paragraph

Article in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meiyun Serena HeDrug Research Unit, Department of Clinical Pharmacy, University of California San Francisco, CA, USA.
Sindy HeDrug Research Unit, Department of Clinical Pharmacy, University of California San Francisco, CA, USA.
Michelle RohOregon Health and Science University, Portland, OR, USA.
Abel KakuruInfectious Disease Research Collaboration, Kampala, Uganda.
Prasanna JagannathanStanford Maternal and Child Health Research Institute, Stanford University, USA.
Grant DorseyDepartment of Medicine, University of California San Francisco, USA.
Philip RosenthalDepartment of Medicine, University of California San Francisco, USA.
Francesca AweekaDrug Research Unit, Department of Clinical Pharmacy, University of California San Francisco, CA, USA.
Liusheng HuangDrug Research Unit, Department of Clinical Pharmacy, University of California San Francisco, CA, USA. Electronic address: Liusheng.huang@ucsf.edu.

Funding

Enhancing immunity to malaria in young children with effective chemopreventionU01AI155325 · NIAID · STANFORD UNIVERSITY · PI JAGANNATHAN, PRASANNA · 2021 to 2025
$6.3M
Precise field-friendly methods for quantification of antimalarial drugs in dried blood spotsR21AI185534 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LIUSHENG · 2024 to 2025
$451k
NIAID NIH HHS R21 AI185534NIAID NIH HHS U01 AI155325
6 · The paper itself

Abstract

Piperaquine (PPQ) is an antimalarial drug used in combination with dihydroartemisinin. To support pharmacokinetic studies of PPQ in children and resource-limited settings, we developed assays to determine PPQ in dried blood samples (DBS) collected with Capitainer devices (10 μL blood) and in 10 μL plasma samples. Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was employed. DBS samples were soaked with 1% HCl to extract PPQ into solution followed by neutralization with NH

Indexed as

AntimalarialsDried Blood Spot TestingLiquid Chromatography-Mass SpectrometryQuinolinesTandem Mass SpectrometryChromatography, High Pressure LiquidHumansLimit of DetectionLinear ModelsPiperazinesReproducibility of ResultsAntimalarialspiperaquinePiperazinesQuinolinesPediatricPiperaquinePlasmaQuantitative DBSUHPLC-MS/MS

Identifiers

PMID42090845
PMCPMC13313772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.