ArticleRevista da Associacao Medica Brasileira (1992)2026
Six-minute walk test to assess muscular fatigability and mobility in children with congenital myasthenic syndrome: a pilot study.
Article in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aims of this study were to determine whether the six-minute walk test predicts muscular fatigability in ambulant children with congenital myasthenic syndrome and to examine the relationship between the six-minute walk test and mobility tests.
methodsEight children (four girls and four boys) with congenital myasthenic syndrome (mean age: 11.75±3.54 years) were included. Five children had COLQ variants. The distance of each minute for the six-minute walk test was determined to evaluate fatigability. The mobility tests included the 10-m walk/run test, rising from the floor, and climbing up and down four stairs.
resultsThe mean six-minute walk test distance was 463.38±132.59 m. There was no difference between the first and last minute, between the first and last two minutes, and between any of the minutes during the six-minute walk test (p>0.05). The mean times for performing the 10-m walk/run test, rising from the floor, and climbing up and down four stairs were 8.59±3.36, 6.38±4.49, 4.38±5.07, and 3.35±3.69 s, respectively. The strong correlations were determined between six-minute walk test and all the mobility tests, except for climbing down four stairs (p< 0.05, rs=-0.72 to -0.83).
conclusionThe six-minute walk test did not provide sufficient evidence to predict muscular fatigability. However, this preliminary study suggested that the six-minute walk test may be used by clinicians and researchers to assess mobility in congenital myasthenic syndrome.
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