Evidence map›Paper›PMID 42090511›Full record

ArticleScience advances2026

A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation.

Johnathan L Meaders, Alyssa A Rodriguez, Smriti Variyar, SungWoo Park, Alessandro E Cirulli, Karen Oegema, Kevin D Corbett, Arshad Desai

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Johnathan L MeadersDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3272-5466
Alyssa A RodriguezDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Smriti VariyarDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
SungWoo ParkDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0002-6093-5644
Alessandro E CirulliDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0002-6497-1319
Karen OegemaDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8515-7514
Kevin D CorbettDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5854-2388
Arshad DesaiDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5410-1830

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Kinetochore Specification and FunctionR01GM074215 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DESAI, ARSHAD · 2005 to 2025
$8.2M
Analysis of Centrosome DynamicsR01GM074207 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OEGEMA, KAREN F · 2006 to 2025
$6.6M
NIGMS NIH HHS K12 GM068524NIGMS NIH HHS R01 GM074207NIGMS NIH HHS R01 GM074215
6 · The paper itself

Abstract

Accurate chromosome segregation requires dynamic kinetochore-microtubule attachments that, under the regulation of Aurora family kinases, biorient and align replicated chromosomes. In

Indexed as

Aurora Kinase ACaenorhabditis elegans ProteinsChromatinChromosome SegregationKinetochoresMicrotubulesAnimalsCaenorhabditis elegansCarrier ProteinsMicrotubule-Associated ProteinsProtein BindingSpindle ApparatusAurora Kinase ACaenorhabditis elegans ProteinsCarrier ProteinsChromatinMicrotubule-Associated ProteinsTPXL-1 protein, C elegans

Identifiers

PMID42090511
PMCPMC13148335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.