Evidence map›Paper›PMID 42090495›Full record

ArticleScience advances2026

Tunable TriPcides suppress virulence factor secretion during

Hasan Tükenmez, Taylor M Nye, Pardeep Singh, Aaron Mychack, Mari Bonde, Suzanne Hickerson, Chloe L P Obernuefemann, Jerome S Pinkner, Shaochun Zhu, Souvik Sarkar and 14 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Hasan TükenmezNordic BioConsult AB, SE-91332, Holmsund, Sweden.ORCID 0000-0002-2259-6883
Taylor M NyeDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4695-0485
Pardeep SinghDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0003-1151-2936
Aaron MychackDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3983-3889
Mari BondeQureTech Bio AB, SE-90736, Umeå, Sweden.ORCID 0000-0003-4624-4337
Suzanne HickersonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chloe L P ObernuefemannDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jerome S PinknerDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7389-7440
Shaochun ZhuDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0001-9945-6718
Souvik SarkarQureTech Bio AB, SE-90736, Umeå, Sweden.ORCID 0000-0003-1803-2708
Jaideep B BharateDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0003-3269-6228
Ingeborg van der LingenDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
Anh Quoc NtuyenmDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0009-0001-4945-7277
V U Bhaskara RaoDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0002-3488-687X
Anders E G LindgrenDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
Hanna KleinDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0003-0133-3790
Zongsen ZouDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-4770-2144
Karen W DodsonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Suzanne WalkerDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0545-914X
Andre MateusDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0001-6870-0677
Jörgen JohanssonDepartment of Molecular Biology, Umeå University, SE-90187 Umeå, Sweden.
Michael G CaparonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1171-0772
Fredrik AlmqvistDepartment of Chemistry, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0002-0504-4446
Scott J HultgrenDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8785-564X

Funding

Rational design and synthesis of small molecule inhibitors targeting unique pathogenic mechanisms in Gram- and Gram+ bacteria important in UTIU19AI157797 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2021 to 2025
$11.4M
Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Chemical disarming of drug resistance in Mycobacterium tuberculosisR01AI134847 · NIAID · WASHINGTON UNIVERSITY · PI ALMQVIST, FREDRIK, STALLINGS, CHRISTINA LEIGH · 2018 to 2021
$2.7M
NIAID NIH HHS R01 AI134847NIAID NIH HHS U19 AI157797NIAID NIH HHS U19 AI158028
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) in common bacterial pathogens, including methicillin-resistant

Indexed as

Anti-Bacterial AgentsMethicillin-Resistant Staphylococcus aureusPyridonesStaphylococcal InfectionsStaphylococcus aureusVirulence FactorsAnimalsHumansMiceMicrobial Sensitivity TestsReactive Oxygen SpeciesAnti-Bacterial AgentsPyridonesReactive Oxygen SpeciesVirulence Factors

Identifiers

PMID42090495
PMCPMC13148309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.