Evidence map›Paper›PMID 42090479›Full record

ArticleScience translational medicine2026

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice.

Weimin Tang, Ysabel Li, Elisa Boscolo, Daniel S Kohane, Kathleen Cullion

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weimin TangLaboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7113-9366
Ysabel LiLaboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0007-5905-3114
Elisa BoscoloDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH 45229, USA.ORCID 0000-0002-6996-0419
Daniel S KohaneLaboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5369-5932
Kathleen CullionLaboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9803-656X

Funding

Prolonged duration and triggered local anesthesiaR35GM131728 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI Daniel S Kohane · 2019 to 2026
$5.4M
Venous Malformations (VM): A Murine Model to Identify Therapies to Target AberranR01HL117952 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BOSCOLO, ELISA · 2013 to 2025
$4.9M
Supplement: Developing Nanoparticle Drug Delivery Systems for Venous MalformationsK08HL153782 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Kathleen Cullion · 2022 to 2026
$915k
NHLBI NIH HHS K08 HL153782NHLBI NIH HHS R01 HL117952NIGMS NIH HHS R35 GM131728
6 · The paper itself

Abstract

Venous malformations (VMs) are caused by activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) and Abelson murine leukemia viral oncogene homolog 1 (c-ABL) pathways. Daily oral administration of rapamycin (RAPA), an mTOR pathway inhibitor, has limited effectiveness in promoting lesion regression in patients with

Indexed as

ImidazolesNanoparticlesPolymersPyridazinesSirolimusVascular MalformationsVeinsAnimalsHumansMicePolyethylene GlycolsImidazolesPolyethylene GlycolsPolymersponatinibPyridazinesSirolimus

Identifiers

PMID42090479
PMCPMC13383109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.