ArticleJournal of applied physiology (Bethesda, Md. : 1985)2026
Reflex vasodilation and sweating in response to passive whole body heating are blunted in women with major depressive disorder.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Major depressive disorder (MDD) is associated with alterations in the mechanistic regulation of body temperature, including altered circadian temperature profiles, reduced sweating, and blunted cutaneous vasodilation. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) may affect vascular function and sweating; however, heat stress thermoregulation in MDD and during SSRI or SNRI therapy has not been measured. The purpose of this study was to measure reflex cutaneous vasodilation and sweating responses during passive heating in women with MDD who were non- or chronically treated with either SSRI or SNRI monotherapy. Sixteen women (aged 18-36 yr) with unmedicated MDD, 16 women with SSRI-treated MDD, 16 women with SNRI-treated MDD, and 16 nondepressed women were passively heated using a water-perfused suit to increase core temperature (T
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