ArticleProceedings of the National Academy of Sciences of the United States of America2026
A molecular timer couples organism-wide temporal identity to developmental checkpoints.
Peipei Wu, Jing Wang, Brett Pryor, Isabella Valentino, David F Ritter, Kaiser Loel, Olya Yarychkivska, Shai Shaham, Justin Kinney, Sevinc Ercan and 2 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Jing WangCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Brett PryorCold Spring Harbor Laboratory School of Biological Sciences, Cold Spring Harbor, NY 11724.
Isabella ValentinoCold Spring Harbor Laboratory School of Biological Sciences, Cold Spring Harbor, NY 11724.
Kaiser LoelSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Olya YarychkivskaLaboratory of Developmental Genetics, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-0048-1006 Shai ShahamLaboratory of Developmental Genetics, The Rockefeller University, New York, NY 10065.
Justin KinneySimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.ORCID 0000-0003-1897-3778 Funding
Glial Control of Neuron Development and Function - Administrative SupplementR35NS105094 · NINDS · ROCKEFELLER UNIVERSITY · PI SHAHAM, SHAI · 2018 to 2025
$8.9MA unified quantitative modeling strategy for multiplex assays of variant effectR01HG011787 · NHGRI · COLD SPRING HARBOR LABORATORY · PI JUSTIN B. KINNEY · 2022 to 2026
$4.1MOSCILLATORY GENE EXPRESSION AND THE MAINTENANCE OF TEMPORAL PATTERNINGR01GM117406 · NIGMS · COLD SPRING HARBOR LABORATORY · PI HAMMELL, CHRISTOPHER MARTIN · 2016 to 2025
$4.0MMechanisms of condensin-mediated gene regulation in C. elegansR35GM130311 · NIGMS · NEW YORK UNIVERSITY · PI Sevinc Ercan · 2019 to 2026
$3.3MLinker cell death regulation in C. elegansR01HD103610 · NICHD · ROCKEFELLER UNIVERSITY · PI SHAHAM, SHAI · 2021 to 2025
$1.8MMolecular timekeeping and temporal cell fate specification in C. elegansR01GM155806 · NIGMS · COLD SPRING HARBOR LABORATORY · PI HAMMELL, CHRISTOPHER MARTIN, JOSHUA-TOR, LEEMOR · 2024 to 2025
$1.3MNuclear and chromatin aberrations during non-apoptotic cell death in C. elegans and mammalsK99GM151467 · NIGMS · ROCKEFELLER UNIVERSITY · PI YARYCHKIVSKA, OLGA · 2023 to 2024
$250kHHS | NIH | National Human Genome Research Institute (NHGRI) R01HG011787HHS | NIH (NIH) K99GM151467HHS | NIH (NIH) R01GM117406HHS | NIH (NIH) R01GM155806HHS | NIH (NIH) R01HD103610HHS | NIH (NIH) R35GM130311HHS | NIH (NIH) R35NS105094NIGMS NIH HHS R01 GM117406NIGMS NIH HHS R01 GM155806NSF (NSF) 2217560
6 · The paper itselfAbstract
Coordinated development requires that growth and cell-fate transitions occur in a defined temporal order across tissues, yet how multicellular organisms generate and synchronize developmental timing information remains unclear. In
Indexed as
Caenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalTranscription FactorsAnimalsMicroRNAsCaenorhabditis elegans Proteinslet-7 microRNA, C elegansLIN-42 protein, C elegansMicroRNAsTranscription Factorscheckpointdevelopmental ClockheterochronicmicroRNAtemproal patterning
Identifiers
PMID42090252
PMCPMC13167726
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