Evidence map›Paper›PMID 42090249›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Functional dissection of

Seong Kyun Park, Jeongha Lee, Seon Ju Park, Ye Na Kim, Gi Hyun Shin, Kisoon Dan, Hee-Jung Choi, Dohyun Han, Byung Joon Hwang, Murim Choi

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Functional dissection ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seong Kyun ParkDepartment of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Jeongha LeeDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.ORCID 0000-0003-4141-3015
Seon Ju ParkDepartment of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Ye Na KimDepartment of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Gi Hyun ShinDepartment of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Kisoon DanProteomics and Metabolomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul 08032, Republic of Korea.ORCID 0000-0001-7791-1345
Hee-Jung ChoiDepartment of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-1167-1526
Dohyun HanProteomics and Metabolomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul 08032, Republic of Korea.ORCID 0000-0002-0841-1598
Byung Joon HwangDepartment of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.ORCID 0000-0003-2449-0684
Murim ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.ORCID 0000-0002-9195-1455

Funding

Lee Kun-Hee Child Cancer and Rare Disease Project 22B-001-0500National Research Foundation of Korea (NRF) 2019H1A2A1076740National Research Foundation of Korea (NRF) 2021R1I1A1A01055745National Research Foundation of Korea (NRF) 2022M3A9B6082674National Research Foundation of Korea (NRF) NRF-RS-2023-00207857
6 · The paper itself

Abstract

Numerous proteins display pleiotropic functions in different clinical contexts. However, the molecular mechanism underlying such effects is rarely understood. Speckle-type POZ protein (

Indexed as

CarcinogenesisNuclear ProteinsProstatic NeoplasmsRepressor ProteinsAmino AcidsEndometrial NeoplasmsFemaleHumansMaleMutationSaccharomyces cerevisiaeAmino AcidsNuclear ProteinsRepressor ProteinsSPOP protein, humandeep mutational scanninggain-of-functionloss-of-functionSPOPvariants of uuncertain significance

Identifiers

PMID42090249
PMCPMC13167761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.