ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2026
Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract.
Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Special Issue on New Horizons in HIV and Reproductive Health Research.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- The Gut-Vagina Axis.Microorganisms · 2026Review
- Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Tight junction-related proteins in the upper reproductive tract luminal and glandular epithelial cells are regionally regulated across the estrous cycle.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses. Sexually transmitted viruses such as HIV-1 and HSV-2 must overcome the physical and functional barriers of the mucosal surface to establish infection. This review explores the intricate relationship between genital ECs and HIV-1 and HSV-2, emphasizing on how these interactions influence infection outcomes. We examine the innate immune responses of ECs in the upper and lower FGT, highlighting both their similarities and differences. Additionally, we delve into the mechanisms of pathogen recognition and virus-specific innate immune responses of genital ECs to HIV-1 and HSV-2. Deepening our understanding of epithelial-viral interactions is critical for identifying key determinants of susceptibility and resistance to sexually transmitted infections (STIs). Elucidating these mechanisms is essential for developing targeted strategies to enhance mucosal immunity, through novel antiviral therapies, vaccine strategies, or interventions to fortify epithelial defenses. Such advancements have the potential to improve protection against these infections and reduce their global burden.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.