ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026
Biological sex influences immune response to influenza infection in juvenile outbred mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Children are highly susceptible to influenza virus infection and lung inflammation. The majority of studies of influenza pneumonia in mice are in adult, inbred, same-sex mice with limited variation in disease outcomes, unlike what is observed in children. In this study, juvenile outbred mice were challenged with influenza A/California/07/2009 H1N1 virus to examine the temporal effect of infection on lung inflammation in genetically dissimilar male and female mice. In this model, influenza infection induced variable disease severity characterized by viral load, airspace leak and inflammation, and lung function. This response was not only clustered by sex at 3 and 4 days postinfection but also was associated with disease severity by
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