Evidence map›Paper›PMID 42090064›Full record

ArticleArchives of women's mental health2026

Poor mood after oral contraceptive use is associated with increased vulnerability to peripartum depression, premenstrual dysphoric disorder, and higher genetic risk for depression.

Jacqueline Kiewa, Penelope A Lind, Ian B Hickie, Sarah E Medland, Brittany E Mitchell, Christel M Middeldorp, Nicholas G Martin, Naomi R Wray, Enda M Byrne

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In one paragraph

Article in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Jacqueline KiewaInstitute for Molecular Bioscience, University of Queensland, Brisbane, Australia. j.kiewa@uq.edu.au.
Penelope A LindQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Ian B HickieBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Brittany E MitchellQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Christel M MiddeldorpChild Health Research Centre, University of Queensland, Brisbane, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Naomi R WrayInstitute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Enda M ByrneChild Health Research Centre, University of Queensland, Brisbane, Australia. enda.byrne@uq.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study tested whether adverse mood effect of the oral contraceptive pill (OCP) is associated with reproductive depressive episodes, including peripartum depression (PPD), premenstrual dysphoric disorder (PMDD), and perimenopausal depression.

methodIn a sample of 3,547 OCP users from the Australian Genetics of Depression Study, who reported a lifetime depression diagnosis, logistic regression was used to test the association of PPD, PMDD, and perimenopausal depression with OCP adverse mood effect. Polygenic scores (PGS) for major depression (MD) were also tested for association with adverse mood effect. Sensitivity analyses tested for modification of these associations by a history of depression prior to first OCP use (prior depression), or by depression onset before the age of twenty (child/teen depression onset).

resultsAdverse mood effect was reported by 1,342 OCP users (38%). PPD, PMDD, prior depression and child/teen depression onset were significantly associated with adverse mood effect (PPD: Relative Risk (RR) = 1.66,CI=[1.4-2.0], P = 2.0 × 10

conclusionsParticipants who experience an adverse mood effect with OCP use are likely to have higher genetic vulnerability for depression, and experience child/teen depression onset, as well as reproductive depressive episodes such as PPD.

Indexed as

AffectContraceptives, OralDepressionPeripartum PeriodPremenstrual Dysphoric DisorderAdultAustraliaFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMajor Depressive DisorderMiddle AgedPerimenopauseRisk FactorsContraceptives, OralDepressionGeneticsMood effectsOral Contraceptive PillReproductive depression

Identifiers

PMID42090064
PMCPMC13149705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.