Evidence map›Paper›PMID 42090026›Full record

ReviewCurrent microbiology2026

Reactivation and Management of Endogenous Latent Herpesviruses in the Spaceflight Environment.

Biying Zhang, Peijun Han, Yong Liu

Abstract readReview
In one paragraph

Review in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Biying ZhangDepartment of Aerospace Hygiene, Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Peijun HanDepartment of Aerospace Hygiene, Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Yong LiuDepartment of Aerospace Hygiene, Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China. liuyong@fmmu.edu.cn.

Funding

the Innovation Capability Support Program of Shaanxi 2023-CX-TD-66
6 · The paper itself

Abstract

The microgravity, radiation, and high-stress environment of space present unique challenges to astronauts' physical and mental health. In this environment, interactions between the host and pathogens are altered, thereby increasing astronauts' risk of endogenous viral infections. Notably, viral shedding detected during spaceflight does not necessarily indicate clinically significant disease, and the distinction between molecular reactivation, productive viral replication, and symptomatic infection must be carefully considered. This review aims to ensure mission success and enhance space biocapacity and biodefence by summarizing case studies and reactivation mechanisms of endogenous latent herpesviruses, the latest prevention and control strategies, and the challenges posed by host variability and antiviral efficacy in the space environment.

Indexed as

HerpesviridaeHerpesviridae InfectionsSpace FlightVirus ActivationVirus LatencyAstronautsHumansVirus ReplicationWeightlessness

Identifiers

PMID42090026
PMCPMC13149593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.