Evidence map›Paper›PMID 42089953›Full record

SynthesisNeuroradiology2026

Safety and efficacy of combined subdural evacuating port system (SEPS) and middle meningeal artery embolization (MMAE) for chronic subdural hematomas: a systematic review and meta-analysis.

John Jy Zhang, Keng Siang Lee, Rambert Wee, Christen Ong, Sai Liang, Julian Han, Tien Meng Cheong

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

John Jy Zhang *Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.
Keng Siang Lee *Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore. mrkengsianglee@gmail.com.ORCID http://orcid.org/0000-0003-2308-0579
Rambert WeeDepartment of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.
Christen OngYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sai LiangDepartment of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.
Julian HanDepartment of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.
Tien Meng CheongDepartment of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe combined use of the Subdural Evacuating Port System (SEPS) and middle meningeal artery embolization (MMAE) offers a less invasive alternative to conventional surgical drainage of chronic subdural hematomas (cSDH), while potentially maintaining low retreatment rates. We aimed to perform the first systematic review and meta-analysis to evaluate the outcomes of combined SEPS and MMAE in the treatment for cSDH.

methodsSearches of the following three electronic databases were undertaken: Ovid Medline, Ovid Embase, and Cochrane Central Register of Controlled Trials. Searches were performed in each database from its inception until 19th August 2025. The primary outcome was recurrence requiring re-evacuation. Secondary outcomes included perioperative complications, mortality, length of stay (LOS), functional and radiological outcomes.

resultsFour studies comprising 341 cases of SEPS and MMAE were included. Pooled recurrence rate after SEPS and MMAE was 9.1% (95% CI: 5.6-13.2, I

conclusionPreliminary evidence of combined SEPS and MMAE demonstrated its potential to achieve promising retreatment rates for well-selected cSDH patients. However, these results are hypothesis-generating, and prospective randomized controlled trials are required to inform on its feasibility and safety for routine clinical use.

Indexed as

DrainageEmbolization, TherapeuticHematoma, Subdural, ChronicMeningeal ArteriesCombined Modality TherapyHumansRecurrenceTreatment OutcomeChronic subdural hematomaMiddle meningeal artery embolizationOutcomeRecurrenceSubdural evacuating port system

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.